Assessment of Structural Intolerance and Durability
General Structure Information 4kng LGR5 crystal structure of human lgr5-rspo1-rnf43 2.5Å AUTH P.H.CHEN,X.CHEN,Z.LIN,D.FANG,X.HETITL THE STRUCTURAL BASIS OF R-SPONDIN RECOGNITION BY LGR5 ANDTITL 2 RNF43.REF GENES DEV. V. 27 1345 2013REFN ISSN 0890-9369PMID 23756651DOI 10.1101/GAD.219915.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4mr7 GABBR2 crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist cgp54626 2.15Å AUTH Y.GENG,M.BUSH,L.MOSYAK,F.WANG,Q.R.FANTITL STRUCTURAL MECHANISM OF LIGAND ACTIVATION IN HUMAN GABA(B)TITL 2 RECEPTOR.REF NATURE V. 504 254 2013REFN ISSN 0028-0836PMID 24305054DOI 10.1038/NATURE12725 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4o7q AIM2 crystal structure of the f27g aim2 pyrin domain mutant and similarities of its self-association to ded/ded interactions 1.82Å AUTH A.LU,V.KABALEESWARAN,T.FU,V.G.MAGUPALLI,H.WUTITL CRYSTAL STRUCTURE OF THE F27G AIM2 PYD MUTANT ANDTITL 2 SIMILARITIES OF ITS SELF-ASSOCIATION TO DED/DEDTITL 3 INTERACTIONS.REF J.MOL.BIOL. V. 426 1420 2014REFN ISSN 0022-2836PMID 24406744DOI 10.1016/J.JMB.2013.12.029 Variant Set Distributions […]
General Structure Information 3urf TNFSF11 human rankl/opg complex 2.7Å AUTH X.D.LUAN,Q.Y.LU,Y.N.JIANG,S.Y.ZHANG,Q.WANG,H.H.YUAN,AUTH 2 W.M.ZHAO,J.W.WANG,X.Q.WANGTITL CRYSTAL STRUCTURE OF HUMAN RANKL COMPLEXED WITH ITS DECOYTITL 2 RECEPTOR OSTEOPROTEGERINREF J.IMMUNOL. V. 189 245 2012REFN ISSN 0022-1767PMID 22664871DOI 10.4049/JIMMUNOL.1103387 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3urf TNFRSF11B human rankl/opg complex 2.7Å AUTH X.D.LUAN,Q.Y.LU,Y.N.JIANG,S.Y.ZHANG,Q.WANG,H.H.YUAN,AUTH 2 W.M.ZHAO,J.W.WANG,X.Q.WANGTITL CRYSTAL STRUCTURE OF HUMAN RANKL COMPLEXED WITH ITS DECOYTITL 2 RECEPTOR OSTEOPROTEGERINREF J.IMMUNOL. V. 189 245 2012REFN ISSN 0022-1767PMID 22664871DOI 10.4049/JIMMUNOL.1103387 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2bt2 RGS16 structure of the regulator of g-protein signaling 16 1.9Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA- SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1ryu ARID1A solution structure of the swi1 arid -1.0Å AUTH S.KIM,Z.ZHANG,S.UPCHURCH,N.ISERN,Y.CHENTITL STRUCTURE AND DNA-BINDING SITES OF THE SWI1TITL 2 AT-RICH INTERACTION DOMAIN (ARID) SUGGESTTITL 3 DETERMINANTS FOR SEQUENCE-SPECIFIC DNA RECOGNITION.REF J.BIOL.CHEM. V. 279 16670 2004REFN ISSN 0021-9258PMID 14722072DOI 10.1074/JBC.M312115200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2p0a SYN3 the crystal structure of human synapsin iii (syn3) in complex with amppnp 1.9Å AUTH A.P.TURNBULL,C.PHILLIPS,A.C.W.PIKE,J.M.ELKINS,C.GILEADI,AUTH 2 E.SALAH,F.H.NIESEN,N.BURGESS,O.GILEADI,F.GORREC,C.UMEANO,AUTH 3 F.VON DELFT,J.WEIGELT,A.EDWARDS,C.H.ARROWSMITH,M.SUNDSTROM,AUTH 4 D.DOYLETITL THE CRYSTAL STRUCTURE OF HUMAN SYNAPSIN III (SYN3) INTITL 2 COMPLEX WITH AMPPNPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2fic BIN1 the crystal structure of the bar domain from human bin1/amphiphysin ii and its implications for molecular recognition 1.99Å AUTH E.CASAL,L.FEDERICI,W.ZHANG,J.FERNANDEZ-RECIO,E.M.PRIEGO,AUTH 2 R.N.MIGUEL,J.B.DUHADAWAY,G.C.PRENDERGAST,B.F.LUISI,E.D.LAUETITL THE CRYSTAL STRUCTURE OF THE BAR DOMAIN FROM HUMANTITL 2 BIN1/AMPHIPHYSIN II AND ITS IMPLICATIONS FOR MOLECULARTITL 3 RECOGNITIONREF BIOCHEMISTRY V. 45 12917 2006REFN ISSN 0006-2960PMID 17059209DOI 10.1021/BI060717K […]
General Structure Information 4aif AIP aip tpr domain in complex with human hsp90 peptide 2.01Å AUTH R.M.MORGAN,L.C.HERNANDEZ-RAMIREZ,G.TRIVELLIN,L.ZHOU,S.M.ROE,AUTH 2 M.KORBONITS,C.PRODROMOUTITL STRUCTURE OF THE TPR DOMAIN OF AIP: LACK OF CLIENT PROTEINTITL 2 INTERACTION WITH THE C-TERMINAL ALPHA-7 HELIX OF THE TPRTITL 3 DOMAIN OF AIP IS SUFFICIENT FOR PITUITARY ADENOMATITL 4 PREDISPOSITION.REF PLOS ONE V. 7 […]