General Structure Information
| PDB ID | 4aif |
| HGNC Gene Label(s) | AIP |
| Structure Name | aip tpr domain in complex with human hsp90 peptide |
| Resolution | 2.01Å |
| Reference | AUTH R.M.MORGAN,L.C.HERNANDEZ-RAMIREZ,G.TRIVELLIN,L.ZHOU,S.M.ROE,AUTH 2 M.KORBONITS,C.PRODROMOUTITL STRUCTURE OF THE TPR DOMAIN OF AIP: LACK OF CLIENT PROTEINTITL 2 INTERACTION WITH THE C-TERMINAL ALPHA-7 HELIX OF THE TPRTITL 3 DOMAIN OF AIP IS SUFFICIENT FOR PITUITARY ADENOMATITL 4 PREDISPOSITION.REF PLOS ONE V. 7 53339 2012REFN ISSN 1932-6203PMID 23300914DOI 10.1371/JOURNAL.PONE.0053339 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 144 |
| Number Of SNVs | 41 |
| Number Of Permutations | 17107 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.026 |
| p-value | 0.575 |
ClinVar
| Number Of Residues | 144 |
| Number Of SNVs | 9 |
| Number Of Permutations | 4098 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.028 |
| p-value | 0.638 |
Ripley’s K Analysis Plots
ExACClinVar
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 41 |
| Number Of ClinVar SNVs | 7 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | -0.077 |
| p-value | 0.674 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
