General Structure Information
| PDB ID | 4mr7 |
| HGNC Gene Label(s) | GABBR2 |
| Structure Name | crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist cgp54626 |
| Resolution | 2.15Å |
| Reference | AUTH Y.GENG,M.BUSH,L.MOSYAK,F.WANG,Q.R.FANTITL STRUCTURAL MECHANISM OF LIGAND ACTIVATION IN HUMAN GABA(B)TITL 2 RECEPTOR.REF NATURE V. 504 254 2013REFN ISSN 0028-0836PMID 24305054DOI 10.1038/NATURE12725 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 402 |
| Number Of SNVs | 52 |
| Number Of Permutations | 25869 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.038 |
| p-value | 0.016 |
COSMIC
| Number Of Residues | 402 |
| Number Of SNVs | 12 |
| Number Of Permutations | 3331 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.667 |
| p-value | 0.06 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 52 |
| Number Of COSMIC SNVs | 9 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.194 |
| p-value | 0.096 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
