Assessment of Structural Intolerance and Durability
General Structure Information 1wwy TXNL1 solution structure of the duf1000 domain of a thioredoxin-like protein 1 -1.0Å AUTH A.K.GORONCY,S.KOSHIBA,N.TOCHIO,T.TOMIZAWA,M.INOUE,A.TANAKA,AUTH 2 S.SUGANO,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C-TERMINAL DUF1000 DOMAIN OF THETITL 2 HUMAN THIOREDOXIN-LIKE 1 PROTEIN.REF PROTEINS V. 78 2176 2010REFN ISSN 0887-3585PMID 20455272DOI 10.1002/PROT.22719 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2per CLIC2 crystal structure of human chloride intracellular channel protein 2 2.0Å AUTH W.MI,Y.H.LIANG,L.LI,X.D.SUTITL THE CRYSTAL STRUCTURE OF HUMAN CHLORIDETITL 2 INTRACELLULAR CHANNEL PROTEIN 2: A DISULFIDE BONDTITL 3 WITH FUNCTIONAL IMPLICATIONS.REF PROTEINS V. 71 509 2008REFN ISSN 0887-3585PMID 18186468DOI 10.1002/PROT.21922 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3vkm LGALS8 protease-resistant mutant form of human galectin-8 in complex with sialyllactose and lactose 2.98Å AUTH H.YOSHIDA,S.YAMASHITA,M.TERAOKA,A.ITOH,S.NAKAKITA,N.NISHI,AUTH 2 S.KAMITORITITL X-RAY STRUCTURE OF A PROTEASE-RESISTANT MUTANT FORM OF HUMANTITL 2 GALECTIN-8 WITH TWO CARBOHYDRATE RECOGNITION DOMAINSREF FEBS J. V. 279 3937 2012REFN ISSN 1742-464XPMID 22913484DOI 10.1111/J.1742-4658.2012.08753.X Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3ulv TLR3 structure of quaternary complex of human tlr3ecd with three fabs (form2) 3.52Å AUTH J.LUO,G.OBMOLOVA,T.J.MALIA,S.J.WU,K.E.DUFFY,J.D.MARION,AUTH 2 J.K.BELL,P.GE,Z.H.ZHOU,A.TEPLYAKOV,Y.ZHAO,R.J.LAMB,AUTH 3 J.L.JORDAN,L.R.SAN MATEO,R.W.SWEET,G.L.GILLILANDTITL LATERAL CLUSTERING OF TLR3:DSRNA SIGNALING UNITS REVEALED BYTITL 2 TLR3ECD:3FABS QUATERNARY STRUCTURE.REF J.MOL.BIOL. V. 421 112 2012REFN ISSN 0022-2836PMID 22579623DOI 10.1016/J.JMB.2012.05.006 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3ee6 TPP1 crystal structure analysis of tripeptidyl peptidase -i 2.35Å AUTH A.PAL,R.KRAETZNER,T.GRUENE,M.GRAPP,K.SCHREIBER,M.GRONBORG,AUTH 2 H.URLAUB,S.BECKER,A.R.ASIF,J.GARTNER,G.M.SHELDRICK,AUTH 3 R.STEINFELDTITL STRUCTURE OF TRIPEPTIDYL-PEPTIDASE I PROVIDES INSIGHT INTOTITL 2 THE MOLECULAR BASIS OF LATE INFANTILE NEURONAL CEROIDTITL 3 LIPOFUSCINOSISREF J.BIOL.CHEM. V. 284 3976 2009REFN ISSN 0021-9258PMID 19038966DOI 10.1074/JBC.M806947200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4dhf AURKA structure of aurora a mutant bound to biogenidec cpd 15 2.8Å AUTH J.Y.LE BRAZIDEC,A.PASIS,B.TAM,C.BOYKIN,D.WANG,D.J.MARCOTTE,AUTH 2 G.CLAASSEN,J.H.CHONG,J.CHAO,J.FAN,K.NGUYEN,L.SILVIAN,L.LING,AUTH 3 L.ZHANG,M.CHOI,M.TENG,N.PATHAN,S.ZHAO,T.LI,A.TAVERASTITL STRUCTURE-BASED DESIGN OFTITL 2 2,6,7-TRISUBSTITUTED-7H-PYRROLO[2,3-D]PYRIMIDINES AS AURORATITL 3 KINASES INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 22 4033 2012REFN ISSN 0960-894XPMID 22607669DOI 10.1016/J.BMCL.2012.04.085 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3ol2 PLXNB1 receptor-ligand structure of human semaphorin 4d with plexin b1. 2.99Å AUTH B.J.JANSSEN,R.A.ROBINSON,F.PEREZ-BRANGULI,C.H.BELL,AUTH 2 K.J.MITCHELL,C.SIEBOLD,E.Y.JONESTITL STRUCTURAL BASIS OF SEMAPHORIN-PLEXIN SIGNALLING.REF NATURE V. 467 1118 2010REFN ISSN 0028-0836PMID 20877282DOI 10.1038/NATURE09468 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4gmj CNOT1 structure of human not1 mif4g domain co-crystallized with caf1 2.7Å AUTH A.P.PETIT,L.WOHLBOLD,P.BAWANKAR,E.HUNTZINGER,S.SCHMIDT,AUTH 2 E.IZAURRALDE,O.WEICHENRIEDERTITL THE STRUCTURAL BASIS FOR THE INTERACTION BETWEEN THE CAF1TITL 2 NUCLEASE AND THE NOT1 SCAFFOLD OF THE HUMAN CCR4-NOTTITL 3 DEADENYLASE COMPLEXREF NUCLEIC ACIDS RES. V. 40 11058 2012REFN ISSN 0305-1048PMID 22977175DOI 10.1093/NAR/GKS883 Variant Set Distributions […]
General Structure Information 2p0r CAPN9 structure of human calpain 9 in complex with leupeptin 2.5Å AUTH T.L.DAVIS,R.PARAMANATHAN,J.R.WALKER,C.BUTLER-COLE,AUTH 2 P.J.FINERTY JR.,J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURES OF HUMAN MINICALPAINS BOUND TO INHIBITORSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ukm KCNK1 crystal structure of the human two pore domain potassium ion channel k2p1 (twik-1) 3.4Å AUTH A.N.MILLER,S.B.LONGTITL CRYSTAL STRUCTURE OF THE HUMAN TWO-PORE DOMAIN POTASSIUMTITL 2 CHANNEL K2P1.REF SCIENCE V. 335 432 2012REFN ISSN 0036-8075PMID 22282804DOI 10.1126/SCIENCE.1213274 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]