Assessment of Structural Intolerance and Durability
General Structure Information 4e3c IKBKB x-ray crystal structure of human ikk2 in an active conformation 3.98Å AUTH S.POLLEY,D.B.HUANG,A.V.HAUENSTEIN,A.J.FUSCO,X.ZHONG,D.VU,AUTH 2 A.HOFFMANN,I.V.VERMA,G.GHOSH,T.HUAFORDTITL X-RAY CRYSTAL STRUCTURE OF HUMAN IKK2 IN AN ACTIVETITL 2 CONFORMATIONREF PLOS.BIOL. 2013REFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1gum GSTA4 human glutathione transferase a4-4 without ligands 3.0Å AUTH C.M.BRUNS,I.HUBATSCH,M.RIDDERSTROM,B.MANNERVIK,AUTH 2 J.A.TAINERTITL HUMAN GLUTATHIONE TRANSFERASE A4-4 CRYSTALTITL 2 STRUCTURES AND MUTAGENESIS REVEAL THE BASIS OFTITL 3 HIGH CATALYTIC EFFICIENCY WITH TOXIC LIPIDTITL 4 PEROXIDATION PRODUCTSREF J.MOL.BIOL. V. 288 427 1999REFN ISSN 0022-2836PMID 10329152DOI 10.1006/JMBI.1999.2697 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2q5e CTDSP2 crystal structure of human carboxy-terminal domain rna polymerase ii polypeptide a small phosphatase 2 2.51Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,AUTH 2 T.P.DILORENZO,V.MALASHKEVICH,S.R.WASSERMAN,AUTH 3 S.SWAMINATHAN,S.ESWARAMOORTHY,R.AGARWAL,D.KUMARAN,AUTH 4 M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,J.ALVARADO,AUTH 5 U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 6 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3t06 ARHGEF11 crystal structure of the dh/ph fragment of pdzrhogef with n-terminal regulatory elements in complex with human rhoa 2.84Å AUTH J.A.BIELNICKI,A.V.SHKUMATOV,U.DEREWENDA,A.V.SOMLYO,AUTH 2 D.I.SVERGUN,Z.S.DEREWENDATITL INSIGHTS INTO THE MOLECULAR ACTIVATION MECHANISM OF THETITL 2 RHOA-SPECIFIC GUANINE NUCLEOTIDE EXCHANGE FACTOR, PDZRHOGEF.REF J.BIOL.CHEM. V. 286 35163 2011REFN ISSN 0021-9258PMID 21816819DOI 10.1074/JBC.M111.270918 Variant Set Distributions Ripley’s […]
General Structure Information 4hpf KCNU1 structure of the human slo3 gating ring 3.4Å AUTH M.D.LEONETTI,P.YUAN,Y.HSIUNG,R.MACKINNONTITL FUNCTIONAL AND STRUCTURAL ANALYSIS OF THE HUMAN SLO3 PH- ANDTITL 2 VOLTAGE-GATED K+ CHANNEL.REF PROC.NATL.ACAD.SCI.USA V. 109 19274 2012REFN ISSN 0027-8424PMID 23129643DOI 10.1073/PNAS.1215078109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lkn AIP solution structure of the ppiase domain of human aryl-hydrocarbon receptor-interacting protein (aip) -1.0Å AUTH M.LINNERT,Y.J.LIN,A.MANNS,K.HAUPT,A.K.PASCHKE,G.FISCHER,AUTH 2 M.WEIWAD,C.LUECKETITL THE FKBP-TYPE DOMAIN OF THE HUMAN ARYL HYDROCARBONTITL 2 RECEPTOR-INTERACTING PROTEIN REVEALS AN UNUSUAL HSP90TITL 3 INTERACTION.REF BIOCHEMISTRY V. 52 2097 2013REFN ISSN 0006-2960PMID 23418784DOI 10.1021/BI301649M Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3bqr DAPK3 crystal structure of human death associated protein kinase 3 (dapk3) in complex with an imidazo-pyridazine ligand 1.75Å AUTH P.FILIPPAKOPOULOS,P.RELLOS,O.FEDOROV,F.NIESEN,A.C.W.PIKE,AUTH 2 E.S.PILKA,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN DEATH ASSOCIATED PROTEIN KINASE 3TITL 2 (DAPK3) IN COMPLEX WITH AN IMIDAZO-PYRIDAZINE LIGAND.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2csq RIMBP2 solution structure of the second sh3 domain of human rim- binding protein 2 -1.0Å AUTH K.INOUE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND SH3 DOMAIN OFTITL 2 HUMAN RIM-BINDING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4gyy OGT crystal structure of human o-glcnac transferase with udp-5sglcnac and a peptide substrate 1.85Å AUTH M.B.LAZARUS,J.JIANG,T.M.GLOSTER,W.F.ZANDBERG,G.E.WHITWORTH,AUTH 2 D.J.VOCADLO,S.WALKERTITL STRUCTURAL SNAPSHOTS OF THE REACTION COORDINATE FOR O-GLCNACTITL 2 TRANSFERASE.REF NAT.CHEM.BIOL. V. 8 966 2012REFN ISSN 1552-4450PMID 23103939DOI 10.1038/NCHEMBIO.1109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 4bej DNM1L nucleotide-free dynamin 1-like protein (dnm1l, drp1, dlp1) 3.48Å AUTH C.FROHLICH,S.GRABIGER,D.SCHWEFEL,K.FAELBER,E.ROSENBAUM,AUTH 2 J.MEARS,O.ROCKS,O.DAUMKETITL STRUCTURAL INSIGHTS INTO OLIGOMERIZATION AND MITOCHONDRIALTITL 2 REMODELLING OF DYNAMIN 1-LIKE PROTEIN.REF EMBO J. V. 32 1280 2013REFN ISSN 0261-4189PMID 23584531DOI 10.1038/EMBOJ.2013.74 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants