General Structure Information
| PDB ID | 3t06 |
| HGNC Gene Label(s) | ARHGEF11 |
| Structure Name | crystal structure of the dh/ph fragment of pdzrhogef with n-terminal regulatory elements in complex with human rhoa |
| Resolution | 2.84Å |
| Reference | AUTH J.A.BIELNICKI,A.V.SHKUMATOV,U.DEREWENDA,A.V.SOMLYO,AUTH 2 D.I.SVERGUN,Z.S.DEREWENDATITL INSIGHTS INTO THE MOLECULAR ACTIVATION MECHANISM OF THETITL 2 RHOA-SPECIFIC GUANINE NUCLEOTIDE EXCHANGE FACTOR, PDZRHOGEF.REF J.BIOL.CHEM. V. 286 35163 2011REFN ISSN 0021-9258PMID 21816819DOI 10.1074/JBC.M111.270918 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 358 |
| Number Of SNVs | 69 |
| Number Of Permutations | 18810 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.052 |
| p-value | 0.63 |
COSMIC
| Number Of Residues | 358 |
| Number Of SNVs | 6 |
| Number Of Permutations | 4043 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.067 |
| p-value | 0.402 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 69 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.054 |
| p-value | 0.7 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
