General Structure Information
| PDB ID | 3bqr |
| HGNC Gene Label(s) | DAPK3 |
| Structure Name | crystal structure of human death associated protein kinase 3 (dapk3) in complex with an imidazo-pyridazine ligand |
| Resolution | 1.75Å |
| Reference | AUTH P.FILIPPAKOPOULOS,P.RELLOS,O.FEDOROV,F.NIESEN,A.C.W.PIKE,AUTH 2 E.S.PILKA,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN DEATH ASSOCIATED PROTEIN KINASE 3TITL 2 (DAPK3) IN COMPLEX WITH AN IMIDAZO-PYRIDAZINE LIGAND.REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 273 |
| Number Of SNVs | 59 |
| Number Of Permutations | 36633 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.168 |
| p-value | 0.441 |
COSMIC
| Number Of Residues | 273 |
| Number Of SNVs | 5 |
| Number Of Permutations | 559 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.1 |
| p-value | 0.718 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 59 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | -0.387 |
| p-value | 0.368 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
