Assessment of Structural Intolerance and Durability
General Structure Information 2crp RGS5 solution structure of the rgs domain of regulator of g- protein signalling 5 (rgs 5) -1.0Å AUTH H.P.ZHANG,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RGS DOMAIN OF REGULATORTITL 2 OF G-PROTEIN SIGNALLING 5 (RGS 5)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2c0j TRAPPC3 crystal structure of the bet3-trs33 heterodimer 2.2Å AUTH M.-S.KIM,M.-J.YI,K.-H.LEE,J.WAGNER,C.MUNGER,Y.-G.KIM,AUTH 2 M.WHITEWAY,M.CYGLER,B.-H.OH,M.SACHERTITL BIOCHEMICAL AND CRYSTALLOGRAPHIC STUDIES REVEAL A SPECIFICTITL 2 INTERACTION BETWEEN TRAPP SUBUNITS TRS33P AND BET3PREF TRAFFIC V. 6 1183 2005REFN ISSN 1398-9219PMID 16262728DOI 10.1111/J.1600-0854.2005.00352.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3l4v MGAM crystal complex of n-terminal human maltase-glucoamylase with kotalanol 2.1Å AUTH L.SIM,K.JAYAKANTHAN,S.MOHAN,R.NASI,B.D.JOHNSTON,AUTH 2 B.M.PINTO,D.R.ROSETITL NEW GLUCOSIDASE INHIBITORS FROM AN AYURVEDIC HERBALTITL 2 TREATMENT FOR TYPE 2 DIABETES: STRUCTURES ANDTITL 3 INHIBITION OF HUMAN INTESTINAL MALTASE-GLUCOAMYLASETITL 4 WITH COMPOUNDS FROM SALACIA RETICULATA.REF BIOCHEMISTRY V. 49 443 2010REFN ISSN 0006-2960PMID 20039683DOI 10.1021/BI9016457 Variant […]
General Structure Information 3top MGAM crystral structure of the c-terminal subunit of human maltase- glucoamylase in complex with acarbose 2.88Å AUTH L.M.REN,X.H.QIN,X.F.CAO,L.L.WANG,F.BAI,G.BAI,Y.SHENTITL STRUCTURAL INSIGHT INTO SUBSTRATE SPECIFICITY OF HUMANTITL 2 INTESTINAL MALTASE-GLUCOAMYLASEREF PROTEIN CELL V. 2 827 2011REFN ISSN 1674-800XPMID 22058037DOI 10.1007/S13238-011-1105-3 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1z3s ANGPT2 angiopoietin-2 receptor binding domain 2.35Å AUTH W.A.BARTON,D.TZVETKOVA,D.B.NIKOLOVTITL STRUCTURE OF THE ANGIOPOIETIN-2 RECEPTOR BINDINGTITL 2 DOMAIN AND IDENTIFICATION OF SURFACES INVOLVED INTITL 3 TIE2 RECOGNITION.REF STRUCTURE V. 13 825 2005REFN ISSN 0969-2126PMID 15893672DOI 10.1016/J.STR.2005.03.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ysq ARHGEF9 solution structure of the sh3 domain from rho guanine nucleotide exchange factor 9 -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN FROM RHOTITL 2 GUANINE NUCLEOTIDE EXCHANGE FACTOR 9REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4c0d CNOT1 structure of the not module of the human ccr4-not complex (cnot1-cnot2-cnot3) 3.2Å AUTH A.BOLAND,Y.CHEN,T.RAISCH,S.JONAS,D.KUZUOGLU-OZTURK,AUTH 2 L.WOHLBOLD,O.WEICHENRIEDER,E.IZAURRALDETITL STRUCTURE AND ASSEMBLY OF THE NOT MODULE OF THE HUMANTITL 2 CCR4-NOT COMPLEXREF NAT.STRUCT.MOL.BIOL. V. 20 1289 2013REFN ISSN 1545-9993PMID 24121232DOI 10.1038/NSMB.2681 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4jgh SOCS2 structure of the socs2-elongin bc complex bound to an n-terminal fragment of cullin5 3.0Å AUTH Y.K.KIM,M.J.KWAK,B.KU,H.Y.SUH,K.JOO,J.LEE,J.U.JUNG,B.H.OHTITL STRUCTURAL BASIS OF INTERSUBUNIT RECOGNITION IN ELONGINTITL 2 BC-CULLIN 5-SOCS BOX UBIQUITIN-PROTEIN LIGASE COMPLEXES.REF ACTA CRYSTALLOGR.,SECT.D V. 69 1587 2013REFN ISSN 0907-4449PMID 23897481DOI 10.1107/S0907444913011220 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2d3v LILRA5 crystal structure of leukocyte ig-like receptor a5 (lilra5/lir9/ilt11) 1.85Å AUTH M.SHIROISHI,M.KAJIKAWA,K.KUROKI,T.OSE,D.KOHDA,AUTH 2 K.MAENAKATITL CRYSTAL STRUCTURE OF THE HUMAN MONOCYTE-ACTIVATINGTITL 2 RECEPTOR,REF J.BIOL.CHEM. V. 281 19536 2006REFN ISSN 0021-9258PMID 16675463DOI 10.1074/JBC.M603076200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3f8u TAPBP tapasin/erp57 heterodimer 2.6Å AUTH G.DONG,P.A.WEARSCH,D.R.PEAPER,P.CRESSWELL,K.M.REINISCHTITL INSIGHTS INTO MHC CLASS I PEPTIDE LOADING FROM THE STRUCTURETITL 2 OF THE TAPASIN-ERP57 THIOL OXIDOREDUCTASE HETERODIMER.REF IMMUNITY V. 30 21 2009REFN ISSN 1074-7613PMID 19119025DOI 10.1016/J.IMMUNI.2008.10.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants