Assessment of Structural Intolerance and Durability
General Structure Information 2wl1 MEFV pyrin pryspry domain 1.35Å AUTH C.WEINERT,C.GRUETTER,H.ROSCHITZKI-VOSER,P.R.MITTL,AUTH 2 M.G.GRUETTERTITL THE CRYSTAL STRUCTURE OF HUMAN PYRIN B30.2 DOMAIN:TITL 2 IMPLICATIONS FOR MUTATIONS ASSOCIATED WITHTITL 3 FAMILIAL MEDITERRANEAN FEVER.REF J.MOL.BIOL. V. 394 226 2009REFN ISSN 0022-2836PMID 19729025DOI 10.1016/J.JMB.2009.08.059 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vaf CASQ2 crystal structure of human cardiac calsequestrin 3.8Å AUTH E.KIM,B.YOUN,L.KEMPER,C.CAMPBELL,H.MILTING,AUTH 2 M.VARSANYI,C.KANGTITL CHARACTERIZATION OF HUMAN CARDIAC CALSEQUESTRINTITL 2 AND ITS DELETERIOUS MUTANTS.REF J.MOL.BIOL. V. 373 1047 2007REFN ISSN 0022-2836PMID 17881003DOI 10.1016/J.JMB.2007.08.055 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2r5t SGK1 crystal structure of inactive serum and glucocorticoid- regulated kinase 1 in complex with amp-pnp 1.9Å AUTH B.ZHAO,R.LEHR,A.M.SMALLWOOD,T.F.HO,K.MALEY,AUTH 2 T.RANDALL,M.S.HEAD,K.K.KORETKE,C.G.SCHNACKENBERGTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF SERUMTITL 2 AND GLUCOCORTICOID-REGULATED KINASE 1 IN COMPLEXTITL 3 WITH AMP PNP.REF PROTEIN SCI. V. 16 2761 2007REFN ISSN 0961-8368PMID 17965184DOI 10.1110/PS.073161707 Variant Set […]
General Structure Information 3mtt PIK3R2 crystal structure of ish2 domain of human p85beta, northeast structural genomics consortium target hr5531c 3.3Å AUTH C.SCHAUDER,L.C.MA,R.M.KRUG,G.T.MONTELIONE,R.GUANTITL STRUCTURE OF THE ISH2 DOMAIN OF HUMAN PHOSPHATIDYLINOSITOLTITL 2 3-KINASE P85BETA SUBUNIT REVEALS CONFORMATIONAL PLASTICITYTITL 3 IN THE INTERHELICAL TURN REGIONREF ACTA CRYSTALLOGR.,SECT.F V. 66 1567 2010REFN ESSN 1744-3091PMID 21139197DOI 10.1107/S1744309110041333 Variant Set […]
General Structure Information 1uf0 DCLK1 solution structure of the n-terminal dcx domain of human doublecortin-like kinase -1.0Å AUTH K.SAITO,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL DCX DOMAIN OFTITL 2 HUMAN DOUBLECORTIN-LIKE KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ydj CHEK1 discovery of checkpoint kinase inhibitor azd7762 by structure based design and optimization of thiophene carboxamide ureas 1.85Å AUTH V.OZA,S.ASHWELL,L.ALMEIDA,P.BRASSIL,J.BREED,C.DENG,T.GERO,AUTH 2 M.GRONDINE,C.HORN,S.IOANNIDIS,D.LIU,P.LYNE,N.NEWCOMBE,AUTH 3 M.PASS,J.A.READ,S.READY,S.ROWSELL,M.SU,D.TOADER,M.VASBINDER,AUTH 4 D.YU,Y.YU,Y.XUE,S.ZABLUDOFF,J.JANETKATITL DISCOVERY OF CHECKPOINT KINASE INHIBITOR (S)-5-(3-TITL 2 FLUOROPHENYL)-N-(PIPERIDIN-3-YL)-3-UREIDOTHIOPHENE-2-TITL 3 CARBOXAMIDE (AZD7762) BY STRUCTURE-BASED DESIGN ANDTITL 4 OPTIMIZATION OF THIOPHENECARBOXAMIDE UREAS.REF J.MED.CHEM. V. 55 5130 2012REFN […]
General Structure Information 3o35 TRIM24 crystal structure of trim24 phd-bromo complexed with h3(23-31)k27ac peptide 1.76Å AUTH W.W.TSAI,Z.WANG,T.T.YIU,K.C.AKDEMIR,W.XIA,S.WINTER,C.Y.TSAI,AUTH 2 X.SHI,D.SCHWARZER,W.PLUNKETT,B.ARONOW,O.GOZANI,W.FISCHLE,AUTH 3 M.C.HUNG,D.J.PATEL,M.C.BARTONTITL TRIM24 LINKS A NON-CANONICAL HISTONE SIGNATURE TO BREASTTITL 2 CANCER.REF NATURE V. 468 927 2010REFN ISSN 0028-0836PMID 21164480DOI 10.1038/NATURE09542 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2cq3 RBFOX2 solution structure of rna binding domain in rna binding motif protein 9 -1.0Å AUTH K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF RNA BINDING DOMAIN IN RNATITL 2 BINDING MOTIF PROTEIN 9REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4gqb PRMT5 crystal structure of the human prmt5:mep50 complex 2.06Å AUTH S.ANTONYSAMY,Z.BONDAY,R.M.CAMPBELL,B.DOYLE,Z.DRUZINA,AUTH 2 T.GHEYI,B.HAN,L.N.JUNGHEIM,Y.QIAN,C.RAUCH,M.RUSSELL,AUTH 3 J.M.SAUDER,S.R.WASSERMAN,K.WEICHERT,F.S.WILLARD,A.ZHANG,AUTH 4 S.EMTAGETITL CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 109 17960 2012REFN ISSN 0027-8424PMID 23071334DOI 10.1073/PNAS.1209814109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3avr KDM6A catalytic fragment of utx/kdm6a bound with histone h3k27me3 peptide, n-oxyalylglycine, and ni(ii) 1.8Å AUTH T.SENGOKU,S.YOKOYAMATITL STRUCTURAL BASIS FOR HISTONE H3 LYS 27 DEMETHYLATION BYTITL 2 UTX/KDM6AREF GENES DEV. V. 25 2266 2011REFN ISSN 0890-9369PMID 22002947DOI 10.1101/GAD.172296.111 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]