General Structure Information
| PDB ID | 2ydj |
| HGNC Gene Label(s) | CHEK1 |
| Structure Name | discovery of checkpoint kinase inhibitor azd7762 by structure based design and optimization of thiophene carboxamide ureas |
| Resolution | 1.85Å |
| Reference | AUTH V.OZA,S.ASHWELL,L.ALMEIDA,P.BRASSIL,J.BREED,C.DENG,T.GERO,AUTH 2 M.GRONDINE,C.HORN,S.IOANNIDIS,D.LIU,P.LYNE,N.NEWCOMBE,AUTH 3 M.PASS,J.A.READ,S.READY,S.ROWSELL,M.SU,D.TOADER,M.VASBINDER,AUTH 4 D.YU,Y.YU,Y.XUE,S.ZABLUDOFF,J.JANETKATITL DISCOVERY OF CHECKPOINT KINASE INHIBITOR (S)-5-(3-TITL 2 FLUOROPHENYL)-N-(PIPERIDIN-3-YL)-3-UREIDOTHIOPHENE-2-TITL 3 CARBOXAMIDE (AZD7762) BY STRUCTURE-BASED DESIGN ANDTITL 4 OPTIMIZATION OF THIOPHENECARBOXAMIDE UREAS.REF J.MED.CHEM. V. 55 5130 2012REFN ISSN 0022-2623PMID 22551018DOI 10.1021/JM300025R |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 251 |
| Number Of SNVs | 46 |
| Number Of Permutations | 8207 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.303 |
| p-value | 0.248 |
COSMIC
| Number Of Residues | 251 |
| Number Of SNVs | 3 |
| Number Of Permutations | 293 |
| Optimal Distance Threshold | 40.0 |
| K Statistic | 0.333 |
| p-value | 0.09 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
