General Structure Information
| PDB ID | 3avr |
| HGNC Gene Label(s) | KDM6A |
| Structure Name | catalytic fragment of utx/kdm6a bound with histone h3k27me3 peptide, n-oxyalylglycine, and ni(ii) |
| Resolution | 1.8Å |
| Reference | AUTH T.SENGOKU,S.YOKOYAMATITL STRUCTURAL BASIS FOR HISTONE H3 LYS 27 DEMETHYLATION BYTITL 2 UTX/KDM6AREF GENES DEV. V. 25 2266 2011REFN ISSN 0890-9369PMID 22002947DOI 10.1101/GAD.172296.111 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 473 |
| Number Of SNVs | 48 |
| Number Of Permutations | 30029 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.011 |
| p-value | 0.028 |
COSMIC
| Number Of Residues | 473 |
| Number Of SNVs | 13 |
| Number Of Permutations | 9113 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.372 |
| p-value | 0.216 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 48 |
| Number Of COSMIC SNVs | 18 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.09 |
| p-value | 0.018 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
