Assessment of Structural Intolerance and Durability
General Structure Information 4avx HGS hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1.68 a resolution 1.68Å AUTH E.WILLIAMS,P.CANNING,L.SHRESTHA,T.KROJER,M.VOLLMAR,A.SLOWEY,AUTH 2 S.CONWAY,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF THE TANDEM VHS AND FYVE DOMAINS OFTITL 2 HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASETITL 3 SUBSTRATE (HGS-HRS) BOUND TO AN IP2 COMPOUND AT 1.68 […]
General Structure Information 2fim TULP1 structure of the c-terminal domain of human tubby-like protein 1 1.9Å AUTH C.PERSSON,D.OGG,A.G.THORSELL,C.ARROWSMITH,H.BERGLUND,AUTH 2 A.EDWARDS,M.EHN,S.FLODIN,S.GRASLUND,M.HAMMARSTROM,M.HOGBOM,AUTH 3 L.HOLMBERG-SCHIAVONE,T.KOTENYOVA,P.KURSULA,P.NILSSON-EHLE,AUTH 4 P.NORDLUND,T.NYMAN,J.SAGEMARK,P.STENMARK,M.SUNDSTROM,AUTH 5 S.VAN DEN BERG,J.WEIGELT,B.M.HALLBERGTITL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN TUBBY-LIKETITL 2 PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gid ACACB the biotin carboxylase (bc) domain of human acetyl-coa carboxylase 2 (acc2) in complex with soraphen a 2.3Å AUTH B.RAYMER,M.KAVANA,A.PRICE,B.WANG,L.CORCORAN,R.KULATHILA,AUTH 2 J.GROARKE,T.MANNTITL SYNTHESIS AND CHARACTERIZATION OF A BODIPY-LABELEDTITL 2 DERIVATIVE OF SORAPHEN A THAT BINDS TO ACETYL-COATITL 3 CARBOXYLASE.REF BIOORG.MED.CHEM.LETT. V. 19 2804 2009REFN ISSN 0960-894XPMID 19359168DOI 10.1016/J.BMCL.2009.03.107 Variant Set Distributions […]
General Structure Information 2r0o ACTN4 crystal structure of the actin-binding domain of human alpha-actinin-4 mutant(k255e) 2.2Å AUTH S.H.LEE,A.WEINS,D.B.HAYES,M.R.POLLAK,R.DOMINGUEZTITL CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OFTITL 2 ALPHA-ACTININ-4 LYS255GLU MUTANT IMPLICATED IN FOCALTITL 3 SEGMENTAL GLOMERULOSCLEROSIS.REF J.MOL.BIOL. V. 376 317 2008REFN ISSN 0022-2836PMID 18164029DOI 10.1016/J.JMB.2007.11.084 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gb8 XPO1 crystal structure of crm1/snurportin-1 complex 2.9Å AUTH X.DONG,A.BISWAS,K.E.SUEL,L.K.JACKSON,R.MARTINEZ,H.GU,AUTH 2 Y.M.CHOOKTITL STRUCTURAL BASIS FOR LEUCINE-RICH NUCLEAR EXPORT SIGNALTITL 2 RECOGNITION BY CRM1.REF NATURE V. 458 1136 2009REFN ISSN 0028-0836PMID 19339969DOI 10.1038/NATURE07975 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1wlx ACTN4 solution structure of the third spectrin repeat of alpha- actinin-4 -1.0Å AUTH K.KOWALSKI,A.L.MERKEL,G.W.BOOKERTITL SOLUTION STRUCTURE OF THE THIRD SPECTRIN REPEAT OFTITL 2 ALPHA-ACTININ-4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qqm NRP1 crystal structure of the a2b1b2 domains from human neuropilin-1 2.0Å AUTH B.A.APPLETON,P.WU,J.MALONEY,J.YIN,W.C.LIANG,S.STAWICKI,AUTH 2 K.MORTARA,K.K.BOWMAN,J.M.ELLIOTT,W.DESMARAIS,J.F.BAZAN,AUTH 3 A.BAGRI,M.TESSIER-LAVIGNE,A.W.KOCH,Y.WU,R.J.WATTS,C.WIESMANNTITL STRUCTURAL STUDIES OF NEUROPILIN/ANTIBODY COMPLEXES PROVIDETITL 2 INSIGHTS INTO SEMAPHORIN AND VEGF BINDINGREF EMBO J. V. 26 4902 2007REFN ISSN 0261-4189PMID 17989695DOI 10.1038/SJ.EMBOJ.7601906 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4eyj MAPK13 mapk13 complex with inhibitor 2.1Å AUTH Y.G.ALEVY,A.C.PATEL,A.G.ROMERO,D.A.PATEL,J.TUCKER,AUTH 2 W.T.ROSWIT,C.A.MILLER,R.F.HEIER,D.E.BYERS,T.J.BRETT,AUTH 3 M.J.HOLTZMANTITL IL-13-INDUCED AIRWAY MUCUS PRODUCTION IS ATTENUATED BYTITL 2 MAPK13 INHIBITION.REF J.CLIN.INVEST. V. 122 4555 2012REFN ISSN 0021-9738PMID 23187130DOI 10.1172/JCI64896 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2gry KIF2A crystal structure of the human kif2 motor domain in complex with adp 2.35Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN KIF2 MOTOR DOMAIN IN COMPLEXTITL 2 WITH ADPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4a69 HDAC3 structure of hdac3 bound to corepressor and inositol tetraphosphate 2.06Å AUTH P.J.WATSON,L.FAIRALL,G.M.SANTOS,J.W.R.SCHWABETITL STRUCTURE OF HDAC3 BOUND TO CO-REPRESSOR AND INOSITOLTITL 2 TETRAPHOSPHATE.REF NATURE V. 481 335 2012REFN ISSN 0028-0836PMID 22230954DOI 10.1038/NATURE10728 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants