General Structure Information
| PDB ID | 4avx |
| HGNC Gene Label(s) | HGS |
| Structure Name | hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1.68 a resolution |
| Resolution | 1.68Å |
| Reference | AUTH E.WILLIAMS,P.CANNING,L.SHRESTHA,T.KROJER,M.VOLLMAR,A.SLOWEY,AUTH 2 S.CONWAY,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF THE TANDEM VHS AND FYVE DOMAINS OFTITL 2 HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASETITL 3 SUBSTRATE (HGS-HRS) BOUND TO AN IP2 COMPOUND AT 1.68 ATITL 4 RESOLUTIONREF TO BE PUBLISHED |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 218 |
| Number Of SNVs | 27 |
| Number Of Permutations | 7090 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.031 |
| p-value | 0.056 |
COSMIC
| Number Of Residues | 218 |
| Number Of SNVs | 3 |
| Number Of Permutations | 7 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.333 |
| p-value | 0.545 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 27 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.533 |
| p-value | 0.399 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
