General Structure Information
| PDB ID | 3gb8 |
| HGNC Gene Label(s) | XPO1 |
| Structure Name | crystal structure of crm1/snurportin-1 complex |
| Resolution | 2.9Å |
| Reference | AUTH X.DONG,A.BISWAS,K.E.SUEL,L.K.JACKSON,R.MARTINEZ,H.GU,AUTH 2 Y.M.CHOOKTITL STRUCTURAL BASIS FOR LEUCINE-RICH NUCLEAR EXPORT SIGNALTITL 2 RECOGNITION BY CRM1.REF NATURE V. 458 1136 2009REFN ISSN 0028-0836PMID 19339969DOI 10.1038/NATURE07975 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 959 |
| Number Of SNVs | 66 |
| Number Of Permutations | 18472 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.146 |
| p-value | 0.188 |
COSMIC
| Number Of Residues | 959 |
| Number Of SNVs | 12 |
| Number Of Permutations | 3818 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.091 |
| p-value | 0.324 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 66 |
| Number Of COSMIC SNVs | 11 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | -0.013 |
| p-value | 0.683 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
