General Structure Information
| PDB ID | 4a69 |
| HGNC Gene Label(s) | HDAC3 |
| Structure Name | structure of hdac3 bound to corepressor and inositol tetraphosphate |
| Resolution | 2.06Å |
| Reference | AUTH P.J.WATSON,L.FAIRALL,G.M.SANTOS,J.W.R.SCHWABETITL STRUCTURE OF HDAC3 BOUND TO CO-REPRESSOR AND INOSITOLTITL 2 TETRAPHOSPHATE.REF NATURE V. 481 335 2012REFN ISSN 0028-0836PMID 22230954DOI 10.1038/NATURE10728 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 369 |
| Number Of SNVs | 42 |
| Number Of Permutations | 5119 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.007 |
| p-value | 0.955 |
COSMIC
| Number Of Residues | 369 |
| Number Of SNVs | 4 |
| Number Of Permutations | 16 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.333 |
| p-value | 0.315 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 42 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.573 |
| p-value | 0.126 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
