General Structure Information
| PDB ID | 1wlx |
| HGNC Gene Label(s) | ACTN4 |
| Structure Name | solution structure of the third spectrin repeat of alpha- actinin-4 |
| Resolution | -1.0Å |
| Reference | AUTH K.KOWALSKI,A.L.MERKEL,G.W.BOOKERTITL SOLUTION STRUCTURE OF THE THIRD SPECTRIN REPEAT OFTITL 2 ALPHA-ACTININ-4REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 127 |
| Number Of SNVs | 27 |
| Number Of Permutations | 18048 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.481 |
| p-value | 0.022 |
COSMIC
| Number Of Residues | 127 |
| Number Of SNVs | 3 |
| Number Of Permutations | 189 |
| Optimal Distance Threshold | 49.0 |
| K Statistic | 0.667 |
| p-value | 0.396 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 27 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | -0.715 |
| p-value | 0.025 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
