General Structure Information
| PDB ID | 3ukm |
| HGNC Gene Label(s) | KCNK1 |
| Structure Name | crystal structure of the human two pore domain potassium ion channel k2p1 (twik-1) |
| Resolution | 3.4Å |
| Reference | AUTH A.N.MILLER,S.B.LONGTITL CRYSTAL STRUCTURE OF THE HUMAN TWO-PORE DOMAIN POTASSIUMTITL 2 CHANNEL K2P1.REF SCIENCE V. 335 432 2012REFN ISSN 0036-8075PMID 22282804DOI 10.1126/SCIENCE.1213274 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 251 |
| Number Of SNVs | 56 |
| Number Of Permutations | 17567 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.123 |
| p-value | 0.822 |
COSMIC
| Number Of Residues | 251 |
| Number Of SNVs | 4 |
| Number Of Permutations | 352 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.167 |
| p-value | 0.068 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 56 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.158 |
| p-value | 0.159 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
