General Structure Information
| PDB ID | 4dhf |
| HGNC Gene Label(s) | AURKA |
| Structure Name | structure of aurora a mutant bound to biogenidec cpd 15 |
| Resolution | 2.8Å |
| Reference | AUTH J.Y.LE BRAZIDEC,A.PASIS,B.TAM,C.BOYKIN,D.WANG,D.J.MARCOTTE,AUTH 2 G.CLAASSEN,J.H.CHONG,J.CHAO,J.FAN,K.NGUYEN,L.SILVIAN,L.LING,AUTH 3 L.ZHANG,M.CHOI,M.TENG,N.PATHAN,S.ZHAO,T.LI,A.TAVERASTITL STRUCTURE-BASED DESIGN OFTITL 2 2,6,7-TRISUBSTITUTED-7H-PYRROLO[2,3-D]PYRIMIDINES AS AURORATITL 3 KINASES INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 22 4033 2012REFN ISSN 0960-894XPMID 22607669DOI 10.1016/J.BMCL.2012.04.085 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 258 |
| Number Of SNVs | 34 |
| Number Of Permutations | 4687 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.191 |
| p-value | 0.0 |
COSMIC
| Number Of Residues | 258 |
| Number Of SNVs | 7 |
| Number Of Permutations | 2339 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.095 |
| p-value | 0.616 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 34 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.288 |
| p-value | 0.35 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
