Assessment of Structural Intolerance and Durability
General Structure Information 1vzo RPS6KA5 the structure of the n-terminal kinase domain of msk1 reveals a novel autoinhibitory conformation for a dual kinase protein 1.8Å AUTH K.J.SMITH,P.S.CARTER,A.BRIDGES,P.HORROCKS,C.LEWIS,AUTH 2 G.PETTMAN,A.CLARKE,M.BROWN,J.HUGHES,M.WILKINSON,AUTH 3 B.BAX,A.REITHTITL THE STRUCTURE OF MSK1 REVEALS A NOVELTITL 2 AUTOINHIBITORY CONFORMATION FOR A DUAL KINASETITL 3 PROTEINREF STRUCTURE V. 12 1066 2004REFN ISSN 0969-2126PMID 15274926DOI […]
General Structure Information 3lju ADAP1 crystal structure of full length centaurin alpha-1 bound with the head group of pip3 1.7Å AUTH Y.TONG,W.TEMPEL,H.WANG,K.YAMADA,L.SHEN,G.A.SENISTERRA,AUTH 2 F.MACKENZIE,A.H.CHISHTI,H.W.PARKTITL PHOSPHORYLATION-INDEPENDENT DUAL-SITE BINDING OF THE FHATITL 2 DOMAIN OF KIF13 MEDIATES PHOSPHOINOSITIDE TRANSPORT VIATITL 3 CENTAURIN ALPHA1.REF PROC.NATL.ACAD.SCI.USA V. 107 20346 2010REFN ISSN 0027-8424PMID 21057110DOI 10.1073/PNAS.1009008107 Variant Set Distributions Ripley’s K […]
General Structure Information 2ytx CSDE1 solution structure of the second cold-shock domain of the human kiaa0885 protein (unr protein) -1.0Å AUTH A.K.GORONCY,S.KOSHIBA,N.TOCHIO,T.TOMIZAWA,M.INOUE,AUTH 2 S.WATANABE,T.HARADA,A.TANAKA,O.OHARA,T.KIGAWA,S.YOKOYAMATITL THE NMR SOLUTION STRUCTURES OF THE FIVE CONSTITUENTTITL 2 COLD-SHOCK DOMAINS (CSD) OF THE HUMAN UNR (UPSTREAM OFTITL 3 N-RAS) PROTEIN.REF J.STRUCT.FUNCT.GENOM. V. 11 181 2010REFN ISSN 1345-711XPMID 20213426DOI 10.1007/S10969-010-9081-Z Variant […]
General Structure Information 4bgq CDKL5 crystal structure of the human cdkl5 kinase domain 2.0Å AUTH P.CANNING,T.KROJER,S.GOUBIN,P.MAHAJAN,M.VOLLMAR,A.C.W.PIKE,AUTH 2 F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF THE HUMAN CDKL5 KINASE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1olm SEC14L2 supernatant protein factor in complex with rrr-alpha-tocopherylquinone: a link between oxidized vitamin e and cholesterol biosynthesis 1.95Å AUTH A.STOCKER,U.BAUMANNTITL SUPERNATANT PROTEIN FACTOR IN COMPLEX WITHTITL 2 RRR-ALPHA-TOCOPHERYLQUINONE: A LINK BETWEENTITL 3 OXIDIZED VITAMIN E AND CHOLESTEROL BIOSYNTHESISREF J.MOL.BIOL. V. 332 759 2003REFN ISSN 0022-2836PMID 12972248DOI 10.1016/S0022-2836(03)00924-0 Variant Set Distributions Ripley’s […]
General Structure Information 2cv5 HIST1H2BK crystal structure of human nucleosome core particle 2.5Å AUTH Y.TSUNAKA,N.KAJIMURA,S.TATE,K.MORIKAWATITL ALTERATION OF THE NUCLEOSOMAL DNA PATH IN THETITL 2 CRYSTAL STRUCTURE OF A HUMAN NUCLEOSOME CORETITL 3 PARTICLEREF NUCLEIC ACIDS RES. V. 33 3424 2005REFN ISSN 0305-1048PMID 15951514DOI 10.1093/NAR/GKI663 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4dg6 LRP6 crystal structure of domains 1 and 2 of lrp6 2.9Å AUTH G.HOLDSWORTH,P.SLOCOMBE,C.DOYLE,B.SWEENEY,V.VEVERKA,AUTH 2 K.LE RICH,R.J.FRANKLIN,D.BROOKINGS,J.TURNER,J.KENNEDY,AUTH 3 R.GARLISH,J.SHI,L.NEWNHAM,D.MCMILLAN,M.MUZYLAK,M.CARR,AUTH 4 A.J.HENRY,T.CESKA,M.K.ROBINSONTITL CHARACTERIZATION OF THE INTERACTION OF SCLEROSTIN WITH THETITL 2 LRP FAMILY OF WNT CO-RECEPTORSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 4f14 NEBL structure of the sh3 domain of human nebulette in complex with a peptide of xirp2 1.2Å AUTH S.EULITZ,F.SAUER,M.C.PELISSIER,P.BOISGUERIN,S.MOLT,J.SCHULD,AUTH 2 Z.ORFANOS,R.A.KLEY,R.VOLKMER,M.WILMANNS,G.KIRFEL,AUTH 3 P.F.VAN DER VEN,D.O.FURSTTITL IDENTIFICATION OF XIN-REPEAT PROTEINS AS NOVEL LIGANDS OFTITL 2 THE SH3 DOMAINS OF NEBULIN AND NEBULETTE AND ANALYSIS OFTITL 3 THEIR INTERACTION DURING MYOFIBRIL FORMATION AND […]
General Structure Information 1imh NFAT5 tonebp/dna complex 2.86Å AUTH J.C.STROUD,C.LOPEZ-RODRIGUEZ,A.RAO,L.CHENTITL STRUCTURE OF A TONEBP-DNA COMPLEX REVEALS DNATITL 2 ENCIRCLED BY A TRANSCRIPTION FACTOR.REF NAT.STRUCT.BIOL. V. 9 90 2002REFN ISSN 1072-8368PMID 11780147DOI 10.1038/NSB749 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2mbc PTP4A3 solution structure of human holo-prl-3 in complex with vanadate -1.0Å AUTH K.KIM,J.H.SONG,J.JEE,M.R.SHEEN,C.LEE,T.G.LEE,S.RO,J.M.CHO,AUTH 2 W.LEE,T.YAMAZAKI,Y.H.JEON,C.CHEONGTITL STRUCTURE OF HUMAN PRL-3, THE PHOSPHATASE ASSOCIATED WITHTITL 2 CANCER METASTASISREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants