General Structure Information
| PDB ID | 4dg6 |
| HGNC Gene Label(s) | LRP6 |
| Structure Name | crystal structure of domains 1 and 2 of lrp6 |
| Resolution | 2.9Å |
| Reference | AUTH G.HOLDSWORTH,P.SLOCOMBE,C.DOYLE,B.SWEENEY,V.VEVERKA,AUTH 2 K.LE RICH,R.J.FRANKLIN,D.BROOKINGS,J.TURNER,J.KENNEDY,AUTH 3 R.GARLISH,J.SHI,L.NEWNHAM,D.MCMILLAN,M.MUZYLAK,M.CARR,AUTH 4 A.J.HENRY,T.CESKA,M.K.ROBINSONTITL CHARACTERIZATION OF THE INTERACTION OF SCLEROSTIN WITH THETITL 2 LRP FAMILY OF WNT CO-RECEPTORSREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 616 |
| Number Of SNVs | 120 |
| Number Of Permutations | 33721 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.006 |
| p-value | 0.897 |
ClinVar
| Number Of Residues | 616 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1093 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.667 |
| p-value | 0.33 |
COSMIC
| Number Of Residues | 616 |
| Number Of SNVs | 10 |
| Number Of Permutations | 3666 |
| Optimal Distance Threshold | 33.0 |
| K Statistic | 0.756 |
| p-value | 0.033 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 120 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.339 |
| p-value | 0.375 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 120 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 33.0 |
| K Statistic | 0.496 |
| p-value | 0.011 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
