1T2F.C | LDHB

General Structure Information 1t2f LDHB human b lactate dehydrogenase complexed with nad+ and 4- hydroxy-1,2,5-oxadiazole-3-carboxylic acid 3.0Å AUTH A.CAMERON,J.READ,R.TRANTER,V.J.WINTER,R.B.SESSIONS,AUTH 2 R.L.BRADY,L.VIVAS,A.EASTON,H.KENDRICK,S.L.CROFT,AUTH 3 D.BARROS,J.L.LAVANDERA,J.J.MARTIN,F.RISCO,AUTH 4 S.GARCIA-OCHOA,F.J.GAMO,L.SANZ,L.LEON,J.R.RUIZ,AUTH 5 R.GABARRO,A.MALLO,F.G.DE LAS HERASTITL IDENTIFICATION AND ACTIVITY OF A SERIES OFTITL 2 AZOLE-BASED COMPOUNDS WITH LACTATETITL 3 DEHYDROGENASE-DIRECTED ANTI-MALARIAL ACTIVITY.REF J.BIOL.CHEM. V. 279 31429 2004REFN ISSN 0021-9258PMID 15117937DOI 10.1074/JBC.M402433200 Variant […]

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2Y5L.C | FBP1

General Structure Information 2y5l FBP1 orally active aminopyridines as inhibitors of tetrameric fructose 1,6-bisphosphatase 2.2Å AUTH P.HEBEISEN,W.HAAP,B.KUHN,P.MOHR,H.P.WESSEL,U.ZUTTER,AUTH 2 S.KIRCHNER,A.RUF,J.BENZ,C.JOSEPH,R.ALVAREZ-SANCHEZ,M.GUBLER,AUTH 3 B.SCHOTT,A.BENARDEAU,E.TOZZO,E.KITASTITL ORALLY ACTIVE AMINOPYRIDINES AS INHIBITORS OF TETRAMERICTITL 2 FRUCTOSE-1,6-BISPHOSPHATASE.REF BIOORG.MED.CHEM.LETT. V. 21 3237 2011REFN ISSN 0960-894XPMID 21550236DOI 10.1016/J.BMCL.2011.04.044 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants

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1KB4.B | VDR

General Structure Information 1kb4 VDR crystal structure of vdr dna-binding domain bound to a canonical direct repeat with three base pair spacer (dr3) response element 2.8Å AUTH P.L.SHAFFER,D.T.GEWIRTHTITL STRUCTURAL BASIS OF VDR-DNA INTERACTIONS ON DIRECTTITL 2 REPEAT RESPONSE ELEMENTS.REF EMBO J. V. 21 2242 2002REFN ISSN 0261-4189PMID 11980721DOI 10.1093/EMBOJ/21.9.2242 Variant Set Distributions Pathogenic Proximity Analysis […]

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1MMP.A | MMP7

General Structure Information 1mmp MMP7 matrilysin complexed with carboxylate inhibitor 2.3Å AUTH M.F.BROWNER,W.W.SMITH,A.L.CASTELHANOTITL MATRILYSIN-INHIBITOR COMPLEXES: COMMON THEMESTITL 2 AMONG METALLOPROTEASES.REF BIOCHEMISTRY V. 34 6602 1995REFN ISSN 0006-2960PMID 7756291DOI 10.1021/BI00020A004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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1GUH.D | GSTA1

General Structure Information 1guh GSTA1 structure determination and refinement of human alpha class glutathione transferase a1-1, and a comparison with the mu and pi class enzymes 2.6Å AUTH I.SINNING,G.J.KLEYWEGT,S.W.COWAN,P.REINEMER,AUTH 2 H.W.DIRR,R.HUBER,G.L.GILLILAND,R.N.ARMSTRONG,X.JI,AUTH 3 P.G.BOARD,B.OLIN,B.MANNERVIK,T.A.JONESTITL STRUCTURE DETERMINATION AND REFINEMENT OF HUMANTITL 2 ALPHA CLASS GLUTATHIONE TRANSFERASE A1-1, AND ATITL 3 COMPARISON WITH THE MU AND PI CLASS […]

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2WCY.A | C7

General Structure Information 2wcy C7 nmr solution structure of factor i-like modules of complement c7. -1.0Å AUTH M.M.PHELAN,C.T.THAI,D.C.SOARES,R.T.OGATA,AUTH 2 P.N.BARLOW,J.BRAMHAMTITL SOLUTION STRUCTURE OF FACTOR I-LIKE MODULES FROMTITL 2 COMPLEMENT C7 REVEALS A PAIR OF FOLLISTATINTITL 3 DOMAINS IN COMPACT PSEUDOSYMMETRIC ARRANGEMENT.REF J.BIOL.CHEM. V. 284 19637 2009REFN ISSN 0021-9258PMID 19419965DOI 10.1074/JBC.M901993200 Variant Set Distributions Ripley’s K […]

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3TH4.H | F7

General Structure Information 3th4 F7 mg2+ is required for optimal folding of the gamma-carboxyglutamic acid (gla) domains of vitamin k-dependent clotting factors at physiological ca2+ 1.8Å AUTH K.VADIVEL,S.AGAH,A.MESSER,D.CASCIO,S.M.BAJAJ,S.KRISHNASWAMY,AUTH 2 C.T.ESMON,K.PADMANABHAN,S.P.BAJAJTITL MG2+ IS REQUIRED FOR OPTIMAL FOLDING OF THETITL 2 GAMMA-CARBOXYGLUTAMIC ACID (GLA) DOMAINS OF VITAMINTITL 3 K-DEPENDENT CLOTTING FACTORS AT PHYSIOLOGICAL CA2+REF TO BE PUBLISHEDREFN […]

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2KE5.A | RALB

General Structure Information 2ke5 RALB solution structure and dynamics of the small gtpase ralb in its active conformation: significance for effector protein binding -1.0Å AUTH R.B.FENWICK,S.PRASANNAN,L.J.CAMPBELL,D.NIETLISPACH,AUTH 2 K.A.EVETTS,J.CAMONIS,H.R.MOTT,D.OWENTITL SOLUTION STRUCTURE AND DYNAMICS OF THE SMALL GTPASETITL 2 RALB IN ITS ACTIVE CONFORMATION: SIGNIFICANCE FORTITL 3 EFFECTOR PROTEIN BINDINGREF BIOCHEMISTRY V. 48 2192 2009REFN ISSN 0006-2960PMID […]

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3MJG.X | PDGFRB

General Structure Information 3mjg PDGFRB the structure of a platelet derived growth factor receptor complex 2.3Å AUTH A.H.SHIM,H.LIU,P.J.FOCIA,X.CHEN,P.C.LIN,X.HETITL STRUCTURES OF A PLATELET-DERIVED GROWTH FACTOR/PROPEPTIDETITL 2 COMPLEX AND A PLATELET-DERIVED GROWTH FACTOR/RECEPTORTITL 3 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 107 11307 2010REFN ISSN 0027-8424PMID 20534510DOI 10.1073/PNAS.1000806107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]

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3FCX.A | ESD

General Structure Information 3fcx ESD crystal structure of human esterase d 1.5Å AUTH D.WU,Y.LI,G.SONG,D.ZHANG,N.SHAW,Z.J.LIUTITL CRYSTAL STRUCTURE OF HUMAN ESTERASE D: A POTENTIALTITL 2 GENETIC MARKER OF RETINOBLASTOMAREF FASEB J. V. 23 1441 2009REFN ISSN 0892-6638PMID 19126594DOI 10.1096/FJ.08-125286 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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