General Structure Information
| PDB ID | 1guh |
| HGNC Gene Label(s) | GSTA1 |
| Structure Name | structure determination and refinement of human alpha class glutathione transferase a1-1, and a comparison with the mu and pi class enzymes |
| Resolution | 2.6Å |
| Reference | AUTH I.SINNING,G.J.KLEYWEGT,S.W.COWAN,P.REINEMER,AUTH 2 H.W.DIRR,R.HUBER,G.L.GILLILAND,R.N.ARMSTRONG,X.JI,AUTH 3 P.G.BOARD,B.OLIN,B.MANNERVIK,T.A.JONESTITL STRUCTURE DETERMINATION AND REFINEMENT OF HUMANTITL 2 ALPHA CLASS GLUTATHIONE TRANSFERASE A1-1, AND ATITL 3 COMPARISON WITH THE MU AND PI CLASS ENZYMES.REF J.MOL.BIOL. V. 232 192 1993REFN ISSN 0022-2836PMID 8331657DOI 10.1006/JMBI.1993.1376 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 221 |
| Number Of SNVs | 69 |
| Number Of Permutations | 25425 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.331 |
| p-value | 0.016 |
COSMIC
| Number Of Residues | 221 |
| Number Of SNVs | 5 |
| Number Of Permutations | 422 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.1 |
| p-value | 0.362 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 69 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | -0.348 |
| p-value | 0.372 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
