Assessment of Structural Intolerance and Durability
General Structure Information 3vi4 ITGA5 crystal structure of alpha5beta1 integrin headpiece in complex with rgd peptide 2.9Å AUTH M.NAGAE,S.RE,E.MIHARA,T.NOGI,Y.SUGITA,J.TAKAGITITL CRYSTAL STRUCTURE OF ALPHA5BETA1 INTEGRIN ECTODOMAIN: ATOMICTITL 2 DETAILS OF THE FIBRONECTIN RECEPTORREF J.CELL BIOL. V. 197 131 2012REFN ISSN 0021-9525PMID 22451694DOI 10.1083/JCB.201111077 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2h4m HNRNPA1 karyopherin beta2/transportin-m9nls 3.05Å AUTH B.J.LEE,A.E.CANSIZOGLU,T.H.LOUIS,Z.ZHANG,Y.M.CHOOKTITL RULES FOR NUCLEAR LOCALIZATION SEQUENCETITL 2 RECOGNITION BY KARYOPHERIN BETA 2.REF CELL(CAMBRIDGE,MASS.) V. 126 543 2006REFN ISSN 0092-8674PMID 16901787DOI 10.1016/J.CELL.2006.05.049 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1nq0 THRB tr receptor mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the nterminal lbd 2.4Å AUTH B.R.HUBER,M.DESCLOZEAUX,B.L.WEST,S.T.CUNHA-LIMA,H.T.NGUYEN,AUTH 2 J.D.BAXTER,H.A.INGRAHAM,R.J.FLETTERICKTITL THYROID HORMONE RECEPTOR-BETA MUTATIONS CONFERRING HORMONETITL 2 RESISTANCE AND REDUCED COREPRESSOR RELEASE EXHIBIT DECREASEDTITL 3 STABILITY IN THE N-TERMINAL LIGAND-BINDING DOMAINREF MOL.ENDOCRINOL. V. 17 107 2003REFN ISSN 0888-8809PMID […]
General Structure Information 3ujr ENO2 asymmetric complex of human neuron specific enolase-5-pga/pep 1.4Å AUTH J.QIN,G.CHAI,J.M.BREWER,L.L.LOVELACE,L.LEBIODATITL STRUCTURES OF ASYMMETRIC COMPLEXES OF HUMAN NEURON SPECIFICTITL 2 ENOLASE WITH RESOLVED SUBSTRATE AND PRODUCT AND AN ANALOGOUSTITL 3 COMPLEX WITH TWO INHIBITORS INDICATE SUBUNIT INTERACTION ANDTITL 4 INHIBITOR COOPERATIVITY.REF J.INORG.BIOCHEM. V. 111 187 2012REFN ISSN 0162-0134PMID 22437160DOI 10.1016/J.JINORGBIO.2012.02.011 Variant […]
General Structure Information 1hdr QDPR the crystallographic structure of a human dihydropteridine reductase nadh binary complex expressed in escherichia coli by a cdna constructed from its rat homologue 2.5Å AUTH Y.SU,K.I.VARUGHESE,N.H.XUONG,T.L.BRAY,D.J.ROCHE,J.M.WHITELEYTITL THE CRYSTALLOGRAPHIC STRUCTURE OF A HUMAN DIHYDROPTERIDINETITL 2 REDUCTASE NADH BINARY COMPLEX EXPRESSED IN ESCHERICHIA COLITITL 3 BY A CDNA CONSTRUCTED FROM ITS RAT […]
General Structure Information 2py1 FABP1 solution structure of human liver fatty acid binding protein -1.0Å AUTH Y.XU,D.LONG,D.YANGTITL RAPID DATA COLLECTION FOR PROTEIN STRUCTURETITL 2 DETERMINATION BY NMR SPECTROSCOPY.REF J.AM.CHEM.SOC. V. 129 7722 2007REFN ISSN 0002-7863PMID 17536800DOI 10.1021/JA071442E Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ie3 GSTP1 structural basis for the binding of the anti-cancer compound 6-(7- nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (nbdhex) to human glutathione s-transferases 1.8Å AUTH L.FEDERICI,C.LO STERZO,S.PEZZOLA,A.DI MATTEO,F.SCALONI,AUTH 2 G.FEDERICI,A.M.CACCURITITL STRUCTURAL BASIS FOR THE BINDING OF THE ANTICANCER COMPOUNDTITL 2 6-(7-NITRO-2,1,3-BENZOXADIAZOL-4-YLTHIO)HEXANOL TO HUMANTITL 3 GLUTATHIONE S-TRANSFERASESREF CANCER RES. V. 69 8025 2009REFN ISSN 0008-5472PMID 19808963DOI 10.1158/0008-5472.CAN-09-1314 Variant […]
General Structure Information 3bch RPSA crystal structure of the human laminin receptor precursor 2.15Å AUTH K.V.JAMIESON,J.WU,S.R.HUBBARD,D.MERUELOTITL CRYSTAL STRUCTURE OF THE HUMAN LAMININ RECEPTORTITL 2 PRECURSOR.REF J.BIOL.CHEM. V. 283 3002 2008REFN ISSN 0021-9258PMID 18063583DOI 10.1074/JBC.C700206200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dqm RARA revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity 2.75Å AUTH S.WANG,Z.WANG,S.LIN,W.ZHENG,R.WANG,S.JIN,J.CHEN,L.JIN,Y.LITITL REVEALING A NATURAL MARINE PRODUCT AS A NOVEL AGONIST FORTITL 2 RETINOIC ACID RECEPTORS WITH A UNIQUE BINDING MODE ANDTITL 3 INHIBITORY EFFECTS ON CANCER CELLS.REF […]
General Structure Information 1z8d PYGM crystal structure of human muscle glycogen phosphorylase a with amp and glucose 2.3Å AUTH C.M.LUKACS,N.G.OIKONOMAKOS,R.L.CROWTHER,L.N.HONG,AUTH 2 R.U.KAMMLOTT,W.LEVIN,S.LI,C.M.LIU,D.LUCAS-MCGADY,AUTH 3 S.PIETRANICO,L.REIKTITL THE CRYSTAL STRUCTURE OF HUMAN MUSCLE GLYCOGEN PHOSPHORYLASETITL 2 A WITH BOUND GLUCOSE AND AMP: AN INTERMEDIATE CONFORMATIONTITL 3 WITH T-STATE AND R-STATE FEATURES.REF PROTEINS V. 63 1123 2006REFN ISSN 0887-3585PMID […]