General Structure Information
| PDB ID | 4dqm |
| HGNC Gene Label(s) | RARA |
| Structure Name | revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity |
| Resolution | 2.75Å |
| Reference | AUTH S.WANG,Z.WANG,S.LIN,W.ZHENG,R.WANG,S.JIN,J.CHEN,L.JIN,Y.LITITL REVEALING A NATURAL MARINE PRODUCT AS A NOVEL AGONIST FORTITL 2 RETINOIC ACID RECEPTORS WITH A UNIQUE BINDING MODE ANDTITL 3 INHIBITORY EFFECTS ON CANCER CELLS.REF BIOCHEM.J. V. 446 79 2012REFN ISSN 0264-6021PMID 22642567DOI 10.1042/BJ20120726 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 234 |
| Number Of SNVs | 28 |
| Number Of Permutations | 3388 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.071 |
| p-value | 0.386 |
COSMIC
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 28 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | -0.36 |
| p-value | 0.589 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
