General Structure Information
| PDB ID | 3ie3 |
| HGNC Gene Label(s) | GSTP1 |
| Structure Name | structural basis for the binding of the anti-cancer compound 6-(7- nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (nbdhex) to human glutathione s-transferases |
| Resolution | 1.8Å |
| Reference | AUTH L.FEDERICI,C.LO STERZO,S.PEZZOLA,A.DI MATTEO,F.SCALONI,AUTH 2 G.FEDERICI,A.M.CACCURITITL STRUCTURAL BASIS FOR THE BINDING OF THE ANTICANCER COMPOUNDTITL 2 6-(7-NITRO-2,1,3-BENZOXADIAZOL-4-YLTHIO)HEXANOL TO HUMANTITL 3 GLUTATHIONE S-TRANSFERASESREF CANCER RES. V. 69 8025 2009REFN ISSN 0008-5472PMID 19808963DOI 10.1158/0008-5472.CAN-09-1314 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 209 |
| Number Of SNVs | 73 |
| Number Of Permutations | 23303 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.023 |
| p-value | 0.905 |
COSMIC
| Number Of Residues | 209 |
| Number Of SNVs | 3 |
| Number Of Permutations | 109 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 73 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.242 |
| p-value | 0.731 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
