General Structure Information
| PDB ID | 3th4 |
| HGNC Gene Label(s) | F7 |
| Structure Name | mg2+ is required for optimal folding of the gamma-carboxyglutamic acid (gla) domains of vitamin k-dependent clotting factors at physiological ca2+ |
| Resolution | 1.8Å |
| Reference | AUTH K.VADIVEL,S.AGAH,A.MESSER,D.CASCIO,S.M.BAJAJ,S.KRISHNASWAMY,AUTH 2 C.T.ESMON,K.PADMANABHAN,S.P.BAJAJTITL MG2+ IS REQUIRED FOR OPTIMAL FOLDING OF THETITL 2 GAMMA-CARBOXYGLUTAMIC ACID (GLA) DOMAINS OF VITAMINTITL 3 K-DEPENDENT CLOTTING FACTORS AT PHYSIOLOGICAL CA2+REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 231 |
| Number Of SNVs | 81 |
| Number Of Permutations | 26017 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.034 |
| p-value | 0.045 |
ClinVar
| Number Of Residues | 231 |
| Number Of SNVs | 5 |
| Number Of Permutations | 329 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.2 |
| p-value | 0.588 |
COSMIC
| Number Of Residues | 231 |
| Number Of SNVs | 7 |
| Number Of Permutations | 424 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.048 |
| p-value | 0.476 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 81 |
| Number Of ClinVar SNVs | 5 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.131 |
| p-value | 0.503 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 81 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | -0.14 |
| p-value | 0.477 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
