Assessment of Structural Intolerance and Durability
General Structure Information 3ojy C8A crystal structure of human complement component c8 2.51Å AUTH L.L.LOVELACE,C.L.COOPER,J.M.SODETZ,L.LEBIODATITL STRUCTURE OF HUMAN C8 PROTEIN PROVIDES MECHANISTIC INSIGHTTITL 2 INTO MEMBRANE PORE FORMATION BY COMPLEMENT.REF J.BIOL.CHEM. V. 286 17585 2011REFN ISSN 0021-9258PMID 21454577DOI 10.1074/JBC.M111.219766 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4g1m ITGAV re-refinement of alpha v beta 3 structure 2.9Å AUTH X.DONG,L.Z.MI,J.ZHU,W.WANG,P.HU,B.H.LUO,T.A.SPRINGERTITL ALPHA V BETA 3 INTEGRIN CRYSTAL STRUCTURES AND THEIRTITL 2 FUNCTIONAL IMPLICATIONSREF BIOCHEMISTRY V. 51 8814 2012REFN ISSN 0006-2960PMID 23106217DOI 10.1021/BI300734N Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kbt SPTB crystal structure of the ankyrin binding domain of human erythroid beta spectrin (repeats 13-15) in complex with the spectrin binding domain of human erythroid ankyrin (zu5-ank) 2.75Å AUTH J.J.IPSARO,A.MONDRAGONTITL STRUCTURAL BASIS FOR SPECTRIN RECOGNITION BY ANKYRIN.REF BLOOD V. 115 4093 2010REFN ISSN 0006-4971PMID 20101027DOI 10.1182/BLOOD-2009-11-255604 Variant Set Distributions Ripley’s K […]
General Structure Information 3ewu UMPS d312n mutant of human orotidyl-5-monophosphate decarboxylase in complex with 6-acetyl-ump, covalent adduct 1.6Å AUTH D.HEINRICH,U.DIEDERICHSEN,M.G.RUDOLPHTITL LYS314 IS A NUCLEOPHILE IN NON-CLASSICAL REACTIONS OFTITL 2 OROTIDINE-5-MONOPHOSPHATE DECARBOXYLASEREF CHEMISTRY V. 15 6619 2009REFN ISSN 0947-6539PMID 19472232DOI 10.1002/CHEM.200900397 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4elj RB1 crystal structure of the inactive retinoblastoma protein phosphorylated at t373 2.7Å AUTH J.R.BURKE,G.L.HURA,S.M.RUBINTITL STRUCTURES OF INACTIVE RETINOBLASTOMA PROTEIN REVEALTITL 2 MULTIPLE MECHANISMS FOR CELL CYCLE CONTROL.REF GENES DEV. V. 26 1156 2012REFN ISSN 0890-9369PMID 22569856DOI 10.1101/GAD.189837.112 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 4glp CD14 the crystal structure of soluble human cd14 reveals a bent solenoid with a hydrophobic amino-terminal pocket. 4.0Å AUTH S.L.KELLEY,T.LUKK,S.K.NAIR,R.I.TAPPINGTITL THE CRYSTAL STRUCTURE OF HUMAN SOLUBLE CD14 REVEALS A BENTTITL 2 SOLENOID WITH A HYDROPHOBIC AMINO-TERMINAL POCKET.REF J.IMMUNOL. V. 190 1304 2013REFN ISSN 0022-1767PMID 23264655DOI 10.4049/JIMMUNOL.1202446 Variant Set Distributions Ripley’s K […]
General Structure Information 1xfb ALDOC human brain fructose 1,6-(bis)phosphate aldolase (c isozyme) 3.0Å AUTH T.L.ARAKAKI,J.A.PEZZA,M.A.CRONIN,C.E.HOPKINS,AUTH 2 D.B.ZIMMER,D.R.TOLAN,K.N.ALLENTITL STRUCTURE OF HUMAN BRAIN FRUCTOSETITL 2 1,6-(BIS)PHOSPHATE ALDOLASE: LINKING ISOZYMETITL 3 STRUCTURE WITH FUNCTIONREF PROTEIN SCI. V. 13 3077 2004REFN ISSN 0961-8368PMID 15537755DOI 10.1110/PS.04915904 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3rhk MET crystal structure of the catalytic domain of c-met kinase in complex with arq 197 1.94Å AUTH S.EATHIRAJ,R.PALMA,E.VOLCKOVA,M.HIRSCHI,D.S.FRANCE,AUTH 2 M.A.ASHWELL,T.C.CHANTITL DISCOVERY OF A NOVEL MODE OF PROTEIN KINASE INHIBITIONTITL 2 CHARACTERIZED BY THE MECHANISM OF INHIBITION OF HUMANTITL 3 MESENCHYMAL-EPITHELIAL TRANSITION FACTOR (C-MET) PROTEINTITL 4 AUTOPHOSPHORYLATION BY ARQ 197.REF J.BIOL.CHEM. V. […]
General Structure Information 4lvt BCL2 bcl_2-navitoclax (abt-263) complex 2.05Å AUTH A.J.SOUERS,J.D.LEVERSON,E.R.BOGHAERT,S.L.ACKLER,N.D.CATRON,AUTH 2 J.CHEN,B.D.DAYTON,H.DING,S.H.ENSCHEDE,W.J.FAIRBROTHER,AUTH 3 D.C.HUANG,S.G.HYMOWITZ,S.JIN,S.L.KHAW,P.J.KOVAR,L.T.LAM,AUTH 4 J.LEE,H.L.MAECKER,K.C.MARSH,K.D.MASON,M.J.MITTEN,P.M.NIMMER,AUTH 5 A.OLEKSIJEW,C.H.PARK,C.M.PARK,D.C.PHILLIPS,A.W.ROBERTS,AUTH 6 D.SAMPATH,J.F.SEYMOUR,M.L.SMITH,G.M.SULLIVAN,S.K.TAHIR,AUTH 7 C.TSE,M.D.WENDT,Y.XIAO,J.C.XUE,H.ZHANG,R.A.HUMERICKHOUSE,AUTH 8 S.H.ROSENBERG,S.W.ELMORETITL ABT-199, A POTENT AND SELECTIVE BCL-2 INHIBITOR, ACHIEVESTITL 2 ANTITUMOR ACTIVITY WHILE SPARING PLATELETS.REF NAT.MED. (N.Y.) V. 19 202 2013REFN ISSN 1078-8956PMID 23291630DOI 10.1038/NM.3048 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2vct GSTA2 glutathione transferase a2-2 in complex with delta-4- andostrene-3-17-dione 2.1Å AUTH K.TARS,B.OLIN,B.MANNERVIKTITL STRUCTURAL BASIS FOR FEATURING OF STEROIDTITL 2 ISOMERASE ACTIVITY IN ALPHA CLASS GLUTATHIONETITL 3 TRANSFERASES.REF J.MOL.BIOL. V. 397 332 2010REFN ISSN 0022-2836PMID 20083122DOI 10.1016/J.JMB.2010.01.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants