Assessment of Structural Intolerance and Durability
General Structure Information 4f14 NEBL structure of the sh3 domain of human nebulette in complex with a peptide of xirp2 1.2Å AUTH S.EULITZ,F.SAUER,M.C.PELISSIER,P.BOISGUERIN,S.MOLT,J.SCHULD,AUTH 2 Z.ORFANOS,R.A.KLEY,R.VOLKMER,M.WILMANNS,G.KIRFEL,AUTH 3 P.F.VAN DER VEN,D.O.FURSTTITL IDENTIFICATION OF XIN-REPEAT PROTEINS AS NOVEL LIGANDS OFTITL 2 THE SH3 DOMAINS OF NEBULIN AND NEBULETTE AND ANALYSIS OFTITL 3 THEIR INTERACTION DURING MYOFIBRIL FORMATION AND […]
General Structure Information 1imh NFAT5 tonebp/dna complex 2.86Å AUTH J.C.STROUD,C.LOPEZ-RODRIGUEZ,A.RAO,L.CHENTITL STRUCTURE OF A TONEBP-DNA COMPLEX REVEALS DNATITL 2 ENCIRCLED BY A TRANSCRIPTION FACTOR.REF NAT.STRUCT.BIOL. V. 9 90 2002REFN ISSN 1072-8368PMID 11780147DOI 10.1038/NSB749 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2mbc PTP4A3 solution structure of human holo-prl-3 in complex with vanadate -1.0Å AUTH K.KIM,J.H.SONG,J.JEE,M.R.SHEEN,C.LEE,T.G.LEE,S.RO,J.M.CHO,AUTH 2 W.LEE,T.YAMAZAKI,Y.H.JEON,C.CHEONGTITL STRUCTURE OF HUMAN PRL-3, THE PHOSPHATASE ASSOCIATED WITHTITL 2 CANCER METASTASISREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4kng LGR5 crystal structure of human lgr5-rspo1-rnf43 2.5Å AUTH P.H.CHEN,X.CHEN,Z.LIN,D.FANG,X.HETITL THE STRUCTURAL BASIS OF R-SPONDIN RECOGNITION BY LGR5 ANDTITL 2 RNF43.REF GENES DEV. V. 27 1345 2013REFN ISSN 0890-9369PMID 23756651DOI 10.1101/GAD.219915.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4mr7 GABBR2 crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist cgp54626 2.15Å AUTH Y.GENG,M.BUSH,L.MOSYAK,F.WANG,Q.R.FANTITL STRUCTURAL MECHANISM OF LIGAND ACTIVATION IN HUMAN GABA(B)TITL 2 RECEPTOR.REF NATURE V. 504 254 2013REFN ISSN 0028-0836PMID 24305054DOI 10.1038/NATURE12725 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2i4i DDX3X crystal structure of human dead-box rna helicase ddx3x 2.2Å AUTH M.HOGBOM,R.COLLINS,S.VAN DEN BERG,R.-M.JENVERT,T.KARLBERG,AUTH 2 T.KOTENYOVA,A.FLORES,G.B.KARLSSON HEDESTAM,AUTH 3 L.H.HOLMBERG SCHIAVONETITL CRYSTAL STRUCTURE OF CONSERVED DOMAINS 1 AND 2 OF THE HUMANTITL 2 DEAD-BOX HELICASE DDX3X IN COMPLEX WITH THE MONONUCLEOTIDETITL 3 AMPREF J.MOL.BIOL. V. 372 150 2007REFN ISSN 0022-2836PMID 17631897DOI 10.1016/J.JMB.2007.06.050 […]
General Structure Information 4o7q AIM2 crystal structure of the f27g aim2 pyrin domain mutant and similarities of its self-association to ded/ded interactions 1.82Å AUTH A.LU,V.KABALEESWARAN,T.FU,V.G.MAGUPALLI,H.WUTITL CRYSTAL STRUCTURE OF THE F27G AIM2 PYD MUTANT ANDTITL 2 SIMILARITIES OF ITS SELF-ASSOCIATION TO DED/DEDTITL 3 INTERACTIONS.REF J.MOL.BIOL. V. 426 1420 2014REFN ISSN 0022-2836PMID 24406744DOI 10.1016/J.JMB.2013.12.029 Variant Set Distributions […]
General Structure Information 3urf TNFSF11 human rankl/opg complex 2.7Å AUTH X.D.LUAN,Q.Y.LU,Y.N.JIANG,S.Y.ZHANG,Q.WANG,H.H.YUAN,AUTH 2 W.M.ZHAO,J.W.WANG,X.Q.WANGTITL CRYSTAL STRUCTURE OF HUMAN RANKL COMPLEXED WITH ITS DECOYTITL 2 RECEPTOR OSTEOPROTEGERINREF J.IMMUNOL. V. 189 245 2012REFN ISSN 0022-1767PMID 22664871DOI 10.4049/JIMMUNOL.1103387 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2bt2 RGS16 structure of the regulator of g-protein signaling 16 1.9Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA- SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4iqy MACROD2 crystal structure of the human protein-proximal adp-ribosyl-hydrolase macrod2 1.55Å AUTH G.JANKEVICIUS,M.HASSLER,B.GOLIA,V.RYBIN,M.ZACHARIAS,AUTH 2 G.TIMINSZKY,A.G.LADURNERTITL A FAMILY OF MACRODOMAIN PROTEINS REVERSES CELLULARTITL 2 MONO-ADP-RIBOSYLATION.REF NAT.STRUCT.MOL.BIOL. V. 20 508 2013REFN ISSN 1545-9993PMID 23474712DOI 10.1038/NSMB.2523 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants