Assessment of Structural Intolerance and Durability
General Structure Information 2qrv DNMT3A structure of dnmt3a-dnmt3l c-terminal domain complex 2.89Å AUTH D.JIA,R.Z.JURKOWSKA,X.ZHANG,A.JELTSCH,X.CHENGTITL STRUCTURE OF DNMT3A BOUND TO DNMT3L SUGGESTS ATITL 2 MODEL FOR DE NOVO DNA METHYLATION.REF NATURE V. 449 248 2007REFN ISSN 0028-0836PMID 17713477DOI 10.1038/NATURE06146 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rje L3MBTL1 crystal structure of l3mbtl1 in complex with h4k20me2 (residues 17- 25), orthorhombic form ii 1.86Å AUTH J.MIN,A.ALLALI-HASSANI,N.NADY,C.QI,H.OUYANG,Y.LIU,AUTH 2 F.MACKENZIE,M.VEDADI,C.H.ARROWSMITHTITL L3MBTL1 RECOGNITION OF MONO- AND DIMETHYLATED HISTONES.REF NAT.STRUCT.MOL.BIOL. V. 14 1229 2007REFN ISSN 1545-9993PMID 18026117DOI 10.1038/NSMB1340 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3zyj NTNG1 netring1 in complex with ngl1 3.25Å AUTH E.SEIRADAKE,C.H.COLES,P.V.PERESTENKO,K.HARLOS,AUTH 2 R.A.J.MCILHINNEY,A.R.ARICESCU,E.Y.JONESTITL STRUCTURAL BASIS FOR CELL SURFACE PATTERNINGTITL 2 THROUGH NETRING-NGL INTERACTIONS.REF EMBO J. V. 30 4479 2011REFN ISSN 0261-4189PMID 21946559DOI 10.1038/EMBOJ.2011.346 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3f0w NUMBL human numb-like protein, phosphotyrosine interaction domain 2.7Å AUTH L.LEHTIO,M.MOCHE,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.D BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,AUTH 4 I.JOHANSSON,T.KARLBERG,T.KOTENYOVA,M.E.NILSSON,T.NYMAN,AUTH 5 C.PERSSON,J.SAGEMARK,H.SCHUELER,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WIKSTROM,M.WISNIEWSKA,AUTH 7 P.NORDLUNDTITL HUMAN NUMB-LIKE PROTEIN, PHOSPHOTYROSINE INTERACTION DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4h6y FARP1 crystal strucure of the dh-ph-ph domain of farp1 4.09Å AUTH X.HE,Y.C.KUO,T.J.ROSCHE,X.ZHANGTITL STRUCTURAL BASIS FOR AUTOINHIBITION OF THE GUANINETITL 2 NUCLEOTIDE EXCHANGE FACTOR FARP2.REF STRUCTURE V. 21 355 2013REFN ISSN 0969-2126PMID 23375260DOI 10.1016/J.STR.2013.01.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bzc SAMHD1 crystal structure of the tetrameric dgtp-bound wild type samhd1 catalytic core 2.88Å AUTH X.JI,Y.WU,J.YAN,J.MEHRENS,H.YANG,M.DELUCIA,C.HAO,AUTH 2 A.M.GRONENBORN,J.SKOWRONSKI,J.AHN,Y.XIONGTITL MECHANISM OF ALLOSTERIC ACTIVATION OF SAMHD1 BY DGTPREF NAT.STRUCT.MOL.BIOL. V. 20 1304 2013REFN ISSN 1545-9993PMID 24141705DOI 10.1038/NSMB.2692 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4hlj ROBO1 axon guidance receptor 1.8Å AUTH R.BARAK,Y.OPATOWSKYTITL CRYSTAL STRUCTURE OF AXON GUIDANCE RECEPTORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lq3 CHKB crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide 1.42Å AUTH B.S.HONG,A.ALLALI-HASSANI,W.TEMPEL,P.J.FINERTY,F.MACKENZIE,AUTH 2 S.DIMOV,M.VEDADI,H.W.PARKTITL CRYSTAL STRUCTURES OF HUMAN CHOLINE KINASE ISOFORMS INTITL 2 COMPLEX WITH HEMICHOLINIUM-3: SINGLE AMINO ACID NEAR THETITL 3 ACTIVE SITE INFLUENCES INHIBITOR SENSITIVITY.REF J.BIOL.CHEM. V. 285 16330 2010REFN ISSN 0021-9258PMID […]
General Structure Information 3e0l GDA computationally designed ammelide deaminase 2.37Å AUTH P.M.MURPHY,J.M.BOLDUC,J.L.GALLAHER,B.L.STODDARD,AUTH 2 D.BAKERTITL ALTERATION OF ENZYME SPECIFICITY BY COMPUTATIONALTITL 2 LOOP REMODELING AND DESIGN.REF PROC.NATL.ACAD.SCI.USA V. 106 9215 2009REFN ISSN 0027-8424PMID 19470646DOI 10.1073/PNAS.0811070106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2z6e DAAM1 crystal structure of human daam1 fh2 2.8Å AUTH M.YAMASHITA,T.HIGASHI,S.SUETSUGU,Y.SATO,T.IKEDA,AUTH 2 R.SHIRAKAWA,T.KITA,T.TAKENAWA,H.HORIUCHI,S.FUKAI,AUTH 3 O.NUREKITITL CRYSTAL STRUCTURE OF HUMAN DAAM1 FORMIN HOMOLOGY 2TITL 2 DOMAINREF GENES CELLS V. 12 1255 2007REFN ISSN 1356-9597PMID 17986009DOI 10.1111/J.1365-2443.2007.01132.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants