General Structure Information
| PDB ID | 2qrv |
| HGNC Gene Label(s) | DNMT3A |
| Structure Name | structure of dnmt3a-dnmt3l c-terminal domain complex |
| Resolution | 2.89Å |
| Reference | AUTH D.JIA,R.Z.JURKOWSKA,X.ZHANG,A.JELTSCH,X.CHENGTITL STRUCTURE OF DNMT3A BOUND TO DNMT3L SUGGESTS ATITL 2 MODEL FOR DE NOVO DNA METHYLATION.REF NATURE V. 449 248 2007REFN ISSN 0028-0836PMID 17713477DOI 10.1038/NATURE06146 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 270 |
| Number Of SNVs | 53 |
| Number Of Permutations | 40096 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.06 |
| p-value | 0.001 |
COSMIC
| Number Of Residues | 270 |
| Number Of SNVs | 26 |
| Number Of Permutations | 18994 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.04 |
| p-value | 0.559 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 53 |
| Number Of COSMIC SNVs | 16 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.082 |
| p-value | 0.707 |