General Structure Information
| PDB ID | 3lq3 |
| HGNC Gene Label(s) | CHKB |
| Structure Name | crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide |
| Resolution | 1.42Å |
| Reference | AUTH B.S.HONG,A.ALLALI-HASSANI,W.TEMPEL,P.J.FINERTY,F.MACKENZIE,AUTH 2 S.DIMOV,M.VEDADI,H.W.PARKTITL CRYSTAL STRUCTURES OF HUMAN CHOLINE KINASE ISOFORMS INTITL 2 COMPLEX WITH HEMICHOLINIUM-3: SINGLE AMINO ACID NEAR THETITL 3 ACTIVE SITE INFLUENCES INHIBITOR SENSITIVITY.REF J.BIOL.CHEM. V. 285 16330 2010REFN ISSN 0021-9258PMID 20299452DOI 10.1074/JBC.M109.039024 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 339 |
| Number Of SNVs | 117 |
| Number Of Permutations | 19848 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.023 |
| p-value | 0.66 |
COSMIC
| Number Of Residues | 339 |
| Number Of SNVs | 5 |
| Number Of Permutations | 765 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.1 |
| p-value | 0.945 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 117 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.413 |
| p-value | 0.328 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
