General Structure Information
| PDB ID | 2i4i |
| HGNC Gene Label(s) | DDX3X |
| Structure Name | crystal structure of human dead-box rna helicase ddx3x |
| Resolution | 2.2Å |
| Reference | AUTH M.HOGBOM,R.COLLINS,S.VAN DEN BERG,R.-M.JENVERT,T.KARLBERG,AUTH 2 T.KOTENYOVA,A.FLORES,G.B.KARLSSON HEDESTAM,AUTH 3 L.H.HOLMBERG SCHIAVONETITL CRYSTAL STRUCTURE OF CONSERVED DOMAINS 1 AND 2 OF THE HUMANTITL 2 DEAD-BOX HELICASE DDX3X IN COMPLEX WITH THE MONONUCLEOTIDETITL 3 AMPREF J.MOL.BIOL. V. 372 150 2007REFN ISSN 0022-2836PMID 17631897DOI 10.1016/J.JMB.2007.06.050 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 407 |
| Number Of SNVs | 13 |
| Number Of Permutations | 10468 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.038 |
| p-value | 0.677 |
ClinVar
| Number Of Residues | 407 |
| Number Of SNVs | 12 |
| Number Of Permutations | 9917 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.045 |
| p-value | 0.483 |
COSMIC
| Number Of Residues | 407 |
| Number Of SNVs | 27 |
| Number Of Permutations | 29562 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.071 |
| p-value | 0.206 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 13 |
| Number Of ClinVar SNVs | 12 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.104 |
| p-value | 0.205 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 13 |
| Number Of COSMIC SNVs | 23 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.107 |
| p-value | 0.386 |