Assessment of Structural Intolerance and Durability
General Structure Information 3s5l HLA-DRA crystal structure of cd4 mutant bound to hla-dr1 2.1Å AUTH X.X.WANG,Y.LI,Y.YIN,M.MO,Q.WANG,W.GAO,L.WANG,R.A.MARIUZZATITL AFFINITY MATURATION OF HUMAN CD4 BY YEAST SURFACE DISPLAYTITL 2 AND CRYSTAL STRUCTURE OF A CD4-HLA-DR1 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 108 15960 2011REFN ISSN 0027-8424PMID 21900604DOI 10.1073/PNAS.1109438108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4jnl PLAU crystal structure of upa in complex with its inhibitor 4- bromobenzylamine at ph 7.4 2.0Å AUTH X.ZHANG,L.JIANG,B.ZHAO,C.YUAN,M.HUANGTITL HALOGEN BONDS IN THE DESIGN OF SERINE PROTEASE INHIBITORSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lwi HRAS solution structure of h-rast35s mutant protein in complex with kobe2601 -1.0Å AUTH F.SHIMA,Y.YOSHIKAWA,M.YE,M.ARAKI,S.MATSUMOTO,J.LIAO,L.HU,AUTH 2 T.SUGIMOTO,Y.IJIRI,A.TAKEDA,Y.NISHIYAMA,C.SATO,S.MURAOKA,AUTH 3 A.TAMURA,T.OSODA,K.I.TSUDA,T.MIYAKAWA,H.FUKUNISHI,J.SHIMADA,AUTH 4 T.KUMASAKA,M.YAMAMOTO,T.KATAOKATITL IN SILICO DISCOVERY OF SMALL-MOLECULE RAS INHIBITORS THATTITL 2 DISPLAY ANTITUMOR ACTIVITY BY BLOCKING THE RAS-EFFECTORTITL 3 INTERACTION.REF PROC.NATL.ACAD.SCI.USA 2013REFN ESSN 1091-6490PMID 23630290DOI 10.1073/PNAS.1217730110 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4mzr TP53 crystal structure of a polypeptide p53 mutant bound to dna 2.9Å AUTH S.EMAMZADAH,L.TROPIA,I.VINCENTI,B.FALQUET,T.D.HALAZONETISTITL REVERSAL OF THE DNA-BINDING-INDUCED LOOP L1 CONFORMATIONALTITL 2 SWITCH IN AN ENGINEERED HUMAN P53 PROTEIN.REF J.MOL.BIOL. V. 426 936 2014REFN ISSN 0022-2836PMID 24374182DOI 10.1016/J.JMB.2013.12.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3s2k LRP6 structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6. 2.8Å AUTH V.E.AHN,M.L.CHU,H.J.CHOI,D.TRAN,A.ABO,W.I.WEISTITL STRUCTURAL BASIS OF WNT SIGNALING INHIBITION BY DICKKOPFTITL 2 BINDING TO LRP5/6.REF DEV.CELL V. 21 862 2011REFN ISSN 1534-5807PMID 22000856DOI 10.1016/J.DEVCEL.2011.09.003 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2xah KDM1A crystal structure of lsd1-corest in complex with (+)- trans-2-phenylcyclopropyl-1-amine 3.1Å AUTH C.BINDA,S.VALENTE,M.ROMANENGHI,S.PILOTTO,R.CIRILLI,AUTH 2 A.KARYTINOS,G.CIOSSANI,O.A.BOTRUGNO,F.FORNERIS,AUTH 3 M.TARDUGNO,D.E.EDMONDSON,S.MINUCCI,A.MATTEVI,A.MAITITL BIOCHEMICAL, STRUCTURAL, AND BIOLOGICAL EVALUATIONTITL 2 OF TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OFTITL 3 HISTONE DEMETHYLASES LSD1 AND LSD2.REF J.AM.CHEM.SOC. V. 132 6827 2010REFN ISSN 0002-7863PMID 20415477DOI 10.1021/JA101557K Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3uo9 GLS crystal structure of human gac in complex with glutamate and bptes 2.3Å AUTH B.DELABARRE,S.GROSS,C.FANG,Y.GAO,A.JHA,F.JIANG,J.SONG J,AUTH 2 W.WEI,J.B.HUROVTITL FULL-LENGTH HUMAN GLUTAMINASE IN COMPLEX WITH AN ALLOSTERICTITL 2 INHIBITOR.REF BIOCHEMISTRY V. 50 10764 2011REFN ISSN 0006-2960PMID 22049910DOI 10.1021/BI201613D Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3zjy IPO13 crystal structure of importin 13 – rangtp – eif1a complex 3.6Å AUTH M.GRUNWALD,D.LAZZARETTI,F.BONOTITL STRUCTURAL BASIS FOR THE NUCLEAR EXPORT ACTIVITY OFTITL 2 IMPORTIN13.REF EMBO J. V. 32 899 2013REFN ISSN 0261-4189PMID 23435562DOI 10.1038/EMBOJ.2013.29 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ax4 PAPSS2 crystal structure of the kinase domain of human 3- phosphoadenosine 5-phosphosulphate synthetase 2 2.5Å AUTH W.M.RABEH,L.NEDYALKOVA,S.ISMAIL,H.PARK,AUTH 2 C.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREVTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF PAPSS 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1e4j FCGR3B crystal structure of the soluble human fc-gamma receptor iii 2.5Å AUTH P.SONDERMANN,R.HUBER,V.OOSTHUIZEN,U.JACOBTITL THE 3.2-A CRYSTAL STRUCTURE OF THE HUMAN IGG1 FCTITL 2 FRAGMENT-FC GAMMARIII COMPLEX.REF NATURE V. 406 267 2000REFN ISSN 0028-0836PMID 10917521DOI 10.1038/35018508 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants