Assessment of Structural Intolerance and Durability
General Structure Information 3be1 ERBB2 dual specific bh1 fab in complex with the extracellular domain of her2/erbb-2 2.9Å AUTH J.BOSTROM,S.F.YU,D.KAN,B.A.APPLETON,C.V.LEE,K.BILLECI,W.MAN,AUTH 2 F.PEALE,S.ROSS,C.WIESMANN,G.FUHTITL VARIANTS OF THE ANTIBODY HERCEPTIN THAT INTERACT WITH HER2TITL 2 AND VEGF AT THE ANTIGEN BINDING SITEREF SCIENCE V. 323 1610 2009REFN ISSN 0036-8075PMID 19299620DOI 10.1126/SCIENCE.1165480 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1xdm ALDOB structure of human aldolase b associated with hereditary fructose intolerance (a149p), at 291k 3.0Å AUTH A.D.MALAY,K.N.ALLEN,D.R.TOLANTITL STRUCTURE OF THE THERMOLABILE MUTANT ALDOLASE B,TITL 2 A149P: MOLECULAR BASIS OF HEREDITARY FRUCTOSETITL 3 INTOLERANCE.REF J.MOL.BIOL. V. 347 135 2005REFN ISSN 0022-2836PMID 15733923DOI 10.1016/J.JMB.2005.01.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4nt5 VWF crystal structure of human von willebrand factor ctck domain 3.28Å AUTH Y.F.ZHOU,T.A.SPRINGERTITL HIGHLY REINFORCED STRUCTURE OF A C-TERMINAL DIMERIZATIONTITL 2 DOMAIN IN VON WILLEBRAND FACTOR.REF BLOOD V. 123 1785 2014REFN ISSN 0006-4971PMID 24394662DOI 10.1182/BLOOD-2013-11-523639 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2bxe ALB human serum albumin complexed with diflunisal 2.95Å AUTH J.GHUMAN,P.A.ZUNSZAIN,I.PETITPAS,A.A.BHATTACHARYA,AUTH 2 M.OTAGIRI,S.CURRYTITL STRUCTURAL BASIS OF THE DRUG-BINDING SPECIFICITYTITL 2 OF HUMAN SERUM ALBUMIN.REF J.MOL.BIOL. V. 353 38 2005REFN ISSN 0022-2836PMID 16169013DOI 10.1016/J.JMB.2005.07.075 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1onq CD1A crystal structure of cd1a in complex with a sulfatide 2.15Å AUTH D.M.ZAJONC,M.A.ELSLIGER,L.TEYTON,I.A.WILSONTITL CRYSTAL STRUCTURE OF CD1A IN COMPLEX WITH A SULFATIDE SELFTITL 2 ANTIGEN AT A RESOLUTION OF 2.15 A.REF NAT.IMMUNOL. V. 4 808 2003REFN ISSN 1529-2908PMID 12833155DOI 10.1038/NI948 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4g0n RAF1 crystal structure of wt h-ras-gppnhp bound to the rbd of raf kinase 2.45Å AUTH S.K.FETICS,H.GUTERRES,B.M.KEARNEY,G.BUHRMAN,B.MA,R.NUSSINOV,AUTH 2 C.MATTOSTITL ALLOSTERIC EFFECTS OF THE ONCOGENIC RASQ61L MUTANT ONTITL 2 RAF-RBD.REF STRUCTURE V. 23 505 2015REFN ISSN 0969-2126PMID 25684575DOI 10.1016/J.STR.2014.12.017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3bt1 PLAU structure of urokinase receptor, urokinase and vitronectin complex 2.8Å AUTH Q.HUAI,A.ZHOU,L.LIN,A.P.MAZAR,G.C.PARRY,J.CALLAHAN,D.E.SHAW,AUTH 2 B.FURIE,B.C.FURIE,M.HUANGTITL CRYSTAL STRUCTURES OF TWO HUMAN VITRONECTIN, UROKINASE ANDTITL 2 UROKINASE RECEPTOR COMPLEXESREF NAT.STRUCT.MOL.BIOL. V. 15 422 2008REFN ISSN 1545-9993PMID 18376415DOI 10.1038/NSMB.1404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1axi GH1 structural plasticity at the hgh:hghbp interface 2.1Å AUTH S.ATWELL,M.ULTSCH,A.M.DE VOS,J.A.WELLSTITL STRUCTURAL PLASTICITY IN A REMODELED PROTEIN-PROTEINTITL 2 INTERFACE.REF SCIENCE V. 278 1125 1997REFN ISSN 0036-8075PMID 9353194DOI 10.1126/SCIENCE.278.5340.1125 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ly4 TP53 hmgb1-facilitated p53 dna binding occurs via hmg-box/p53 transactivation domain interaction and is regulated by the acidic tail -1.0Å AUTH J.P.ROWELL,K.L.SIMPSON,K.STOTT,M.WATSON,J.O.THOMASTITL HMGB1-FACILITATED P53 DNA BINDING OCCURS VIA HMG-BOX/P53TITL 2 TRANSACTIVATION DOMAIN INTERACTION, REGULATED BY THE ACIDICTITL 3 TAIL.REF STRUCTURE V. 20 2014 2012REFN ISSN 0969-2126PMID 23063560DOI 10.1016/J.STR.2012.09.004 Variant Set Distributions Ripley’s […]
General Structure Information 2xwj C3 crystal structure of complement c3b in complex with factor b 4.0Å AUTH F.FORNERIS,D.RICKLIN,J.WU,A.TZEKOU,R.S.WALLACE,J.D.LAMBRIS,AUTH 2 P.GROSTITL STRUCTURES OF C3B IN COMPLEX WITH FACTORS B AND D GIVETITL 2 INSIGHT INTO COMPLEMENT CONVERTASE FORMATION.REF SCIENCE V. 330 1816 2010REFN ISSN 0036-8075PMID 21205667DOI 10.1126/SCIENCE.1195821 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]