General Structure Information
| PDB ID | 2ly4 |
| HGNC Gene Label(s) | TP53 |
| Structure Name | hmgb1-facilitated p53 dna binding occurs via hmg-box/p53 transactivation domain interaction and is regulated by the acidic tail |
| Resolution | -1.0Å |
| Reference | AUTH J.P.ROWELL,K.L.SIMPSON,K.STOTT,M.WATSON,J.O.THOMASTITL HMGB1-FACILITATED P53 DNA BINDING OCCURS VIA HMG-BOX/P53TITL 2 TRANSACTIVATION DOMAIN INTERACTION, REGULATED BY THE ACIDICTITL 3 TAIL.REF STRUCTURE V. 20 2014 2012REFN ISSN 0969-2126PMID 23063560DOI 10.1016/J.STR.2012.09.004 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 47 |
| Number Of SNVs | 5 |
| Number Of Permutations | 2049 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.8 |
| p-value | 0.221 |
COSMIC
| Number Of Residues | 47 |
| Number Of SNVs | 6 |
| Number Of Permutations | 2021 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.133 |
| p-value | 0.862 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
