Assessment of Structural Intolerance and Durability
General Structure Information 1nzx ALDH2 human mitochondrial aldehyde dehydrogenase complexed with nad+ in the presence of low mg2+ 2.45Å AUTH S.J.PEREZ-MILLER,T.D.HURLEYTITL COENZYME ISOMERIZATION IS INTEGRAL TO CATALYSIS INTITL 2 ALDEHYDE DEHYDROGENASEREF BIOCHEMISTRY V. 42 7100 2003REFN ISSN 0006-2960PMID 12795606DOI 10.1021/BI034182W Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1dgb CAT human erythrocyte catalase 2.2Å AUTH C.D.PUTNAM,A.S.ARVAI,Y.BOURNE,J.A.TAINERTITL ACTIVE AND INHIBITED HUMAN CATALASE STRUCTURES:TITL 2 LIGAND AND NADPH BINDING AND CATALYTIC MECHANISM.REF J.MOL.BIOL. V. 296 295 2000REFN ISSN 0022-2836PMID 10656833DOI 10.1006/JMBI.1999.3458 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ggu F13A1 human factor xiii with calcium bound in the ion site 2.1Å AUTH B.A.FOX,V.C.YEE,L.C.PEDERSEN,I.LE TRONG,P.D.BISHOP,AUTH 2 R.E.STENKAMP,D.C.TELLERTITL IDENTIFICATION OF THE CALCIUM BINDING SITE AND ATITL 2 NOVEL YTTERBIUM SITE IN BLOOD COAGULATION FACTORTITL 3 XIII BY X-RAY CRYSTALLOGRAPHY.REF J.BIOL.CHEM. V. 274 4917 1999REFN ISSN 0021-9258PMID 9988734DOI 10.1074/JBC.274.8.4917 Variant Set Distributions Ripley’s […]
General Structure Information 1li1 COL4A1 the 1.9-a crystal structure of the noncollagenous (nc1) domain of human placenta collagen iv shows stabilization via a novel type of covalent met-lys cross-link 1.9Å AUTH M.E.THAN,S.HENRICH,R.HUBER,A.RIES,K.MANN,K.KUHN,AUTH 2 R.TIMPL,G.P.BOURENKOV,H.D.BARTUNIK,W.BODETITL THE 1.9-A CRYSTAL STRUCTURE OF THE NONCOLLAGENOUSTITL 2 (NC1) DOMAIN OF HUMAN PLACENTA COLLAGEN IV SHOWSTITL 3 STABILIZATION VIA A NOVEL […]
General Structure Information 2hzq APOD crystal structure of human apolipoprotein d (apod) in complex with progesterone 1.8Å AUTH A.EICHINGER,A.NASREEN,H.J.KIM,A.SKERRATITL STRUCTURAL INSIGHT INTO THE DUAL LIGANDTITL 2 SPECIFICITY AND MODE OF HIGH DENSITY LIPOPROTEINTITL 3 ASSOCIATION OF APOLIPOPROTEIN D.REF J.BIOL.CHEM. V. 282 31068 2007REFN ISSN 0021-9258PMID 17699160DOI 10.1074/JBC.M703552200 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2ald ALDOA human muscle aldolase 2.1Å AUTH A.DALBY,Z.DAUTER,J.A.LITTLECHILDTITL CRYSTAL STRUCTURE OF HUMAN MUSCLE ALDOLASE COMPLEXED WITHTITL 2 FRUCTOSE 1,6-BISPHOSPHATE: MECHANISTIC IMPLICATIONS.REF PROTEIN SCI. V. 8 291 1999REFN ISSN 0961-8368PMID 10048322 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1hml LALBA alpha_lactalbumin possesses a distinct zinc binding site 1.7Å AUTH J.REN,D.I.STUART,K.R.ACHARYATITL ALPHA-LACTALBUMIN POSSESSES A DISTINCT ZINCTITL 2 BINDING SITE.REF J.BIOL.CHEM. V. 268 19292 1993REFN ISSN 0021-9258PMID 8366079 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4kro EGFR nanobody/vhh domain ega1 in complex with the extracellular region of egfr 3.05Å AUTH K.R.SCHMITZ,A.BAGCHI,R.C.ROOVERS,AUTH 2 P.M.VAN BERGEN EN HENEGOUWEN,K.M.FERGUSONTITL STRUCTURAL EVALUATION OF EGFR INHIBITION MECHANISMS FORTITL 2 NANOBODIES/VHH DOMAINS.REF STRUCTURE V. 21 1214 2013REFN ISSN 0969-2126PMID 23791944DOI 10.1016/J.STR.2013.05.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2m20 EGFR egfr transmembrane – juxtamembrane (tm-jm) segment in bicelles: md guided nmr refined structure. -1.0Å AUTH N.F.ENDRES,R.DAS,A.W.SMITH,A.ARKHIPOV,E.KOVACS,Y.HUANG,AUTH 2 J.G.PELTON,Y.SHAN,D.E.SHAW,D.E.WEMMER,J.T.GROVES,J.KURIYANTITL CONFORMATIONAL COUPLING ACROSS THE PLASMA MEMBRANE INTITL 2 ACTIVATION OF THE EGF RECEPTOR.REF CELL(CAMBRIDGE,MASS.) V. 152 543 2013REFN ISSN 0092-8674PMID 23374349DOI 10.1016/J.CELL.2012.12.032 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2hdl CXCL14 solution structure of brak/cxcl14 -1.0Å AUTH F.C.PETERSON,J.A.THORPE,A.G.HARDER,B.F.VOLKMAN,AUTH 2 S.R.SCHWARZETITL STRUCTURAL DETERMINANTS INVOLVED IN THE REGULATIONTITL 2 OF CXCL14/BRAK EXPRESSION BY THE 26 S PROTEASOME.REF J.MOL.BIOL. V. 363 813 2006REFN ISSN 0022-2836PMID 16987528DOI 10.1016/J.JMB.2006.08.057 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants