General Structure Information
| PDB ID | 2m20 |
| HGNC Gene Label(s) | EGFR |
| Structure Name | egfr transmembrane – juxtamembrane (tm-jm) segment in bicelles: md guided nmr refined structure. |
| Resolution | -1.0Å |
| Reference | AUTH N.F.ENDRES,R.DAS,A.W.SMITH,A.ARKHIPOV,E.KOVACS,Y.HUANG,AUTH 2 J.G.PELTON,Y.SHAN,D.E.SHAW,D.E.WEMMER,J.T.GROVES,J.KURIYANTITL CONFORMATIONAL COUPLING ACROSS THE PLASMA MEMBRANE INTITL 2 ACTIVATION OF THE EGF RECEPTOR.REF CELL(CAMBRIDGE,MASS.) V. 152 543 2013REFN ISSN 0092-8674PMID 23374349DOI 10.1016/J.CELL.2012.12.032 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 56 |
| Number Of SNVs | 17 |
| Number Of Permutations | 16256 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.228 |
| p-value | 0.066 |
COSMIC
| Number Of Residues | 56 |
| Number Of SNVs | 8 |
| Number Of Permutations | 11202 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.036 |
| p-value | 0.127 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 17 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | -0.192 |
| p-value | 0.01 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
