Assessment of Structural Intolerance and Durability
General Structure Information 1if4 CA2 carbonic anhydrase ii complexed with 4- fluorobenzenesulfonamide 1.93Å AUTH C.-Y.KIM,D.W.CHRISTIANSONTITL BINDING OF FLUORINE SUBSTITUTEDTITL 2 BENZENESULFONAMIDES TO CARBONIC ANHYDRASE IIREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dmu VWF crystal structure of the von willebrand factor a3 domain in complex with a collagen iii derived triple-helical peptide 2.8Å AUTH T.H.BRONDIJK,D.BIHAN,R.W.FARNDALE,E.G.HUIZINGATITL IMPLICATIONS FOR COLLAGEN I CHAIN REGISTRY FROM THETITL 2 STRUCTURE OF THE COLLAGEN VON WILLEBRAND FACTOR A3 DOMAINTITL 3 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 109 5253 2012REFN ISSN 0027-8424PMID 22440751DOI 10.1073/PNAS.1112388109 […]
General Structure Information 3i6w CHEK2 structure and activation mechanism of the chk2 dna-damage checkpoint kinase 3.25Å AUTH Z.CAI,N.H.CHEHAB,N.P.PAVLETICHTITL STRUCTURE AND ACTIVATION MECHANISM OF THE CHK2 DNA DAMAGETITL 2 CHECKPOINT KINASE.REF MOL.CELL V. 35 818 2009REFN ISSN 1097-2765PMID 19782031DOI 10.1016/J.MOLCEL.2009.09.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2q80 GGPS1 crystal structure of human geranylgeranyl pyrophosphate synthase bound to ggpp 2.7Å AUTH K.L.KAVANAGH,J.E.DUNFORD,G.BUNKOCZI,R.G.RUSSELL,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN GERANYLGERANYL PYROPHOSPHATETITL 2 SYNTHASE REVEALS A NOVEL HEXAMERIC ARRANGEMENT ANDTITL 3 INHIBITORY PRODUCT BINDINGREF J.BIOL.CHEM. V. 281 22004 2006REFN ISSN 0021-9258PMID 16698791DOI 10.1074/JBC.M602603200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3v83 TF the 2.1 angstrom crystal structure of diferric human transferrin 2.1Å AUTH N.NOINAJ,N.C.EASLEY,M.OKE,N.MIZUNO,J.GUMBART,E.BOURA,AUTH 2 A.N.STEERE,O.ZAK,P.AISEN,E.TAJKHORSHID,R.W.EVANS,AUTH 3 A.R.GORRINGE,A.B.MASON,A.C.STEVEN,S.K.BUCHANANTITL STRUCTURAL BASIS FOR IRON PIRACY BY PATHOGENIC NEISSERIA.REF NATURE V. 483 53 2012REFN ISSN 0028-0836PMID 22327295DOI 10.1038/NATURE10823 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4acq A2M alpha-2 macroglobulin 4.3Å AUTH A.MARRERO,S.DUQUERROY,S.TRAPANI,T.GOULAS,T.GUEVARA,AUTH 2 G.R.ANDERSEN,J.NAVAZA,L.SOTTRUP-JENSEN,F.X.GOMIS-RUTHTITL THE CRYSTAL STRUCTURE OF HUMAN ALPHA(2)-MACROGLOBULINTITL 2 REVEALS A UNIQUE MOLECULAR CAGE.REF ANGEW.CHEM.INT.ED.ENGL. V. 51 3340 2012REFN ISSN 1433-7851PMID 22290936DOI 10.1002/ANIE.201108015 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zed ALPP alkaline phosphatase from human placenta in complex with p- nitrophenyl-phosphonate 1.57Å AUTH P.LLINAS,E.A.STURA,A.MENEZ,Z.KISS,T.STIGBRAND,J.L.MILLAN,AUTH 2 M.H.LE DUTITL STRUCTURAL STUDIES OF HUMAN PLACENTAL ALKALINE PHOSPHATASETITL 2 IN COMPLEX WITH FUNCTIONAL LIGANDS.REF J.MOL.BIOL. V. 350 441 2005REFN ISSN 0022-2836PMID 15946677DOI 10.1016/J.JMB.2005.04.068 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4jnk LDHA lactate dehydrogenase a in complex with inhibitor compound 22 1.9Å AUTH P.S.DRAGOVICH,B.P.FAUBER,L.B.CORSON,C.Z.DING,C.EIGENBROT,AUTH 2 H.GE,A.M.GIANNETTI,T.HUNSAKER,S.LABADIE,Y.LIU,S.MALEK,B.PAN,AUTH 3 D.PETERSON,K.PITTS,H.E.PURKEY,S.SIDERIS,M.ULTSCH,AUTH 4 E.VANDERPORTEN,B.WEI,Q.XU,I.YEN,Q.YUE,H.ZHANG,X.ZHANGTITL IDENTIFICATION OF SUBSTITUTEDTITL 2 2-THIO-6-OXO-1,6-DIHYDROPYRIMIDINES AS INHIBITORS OF HUMANTITL 3 LACTATE DEHYDROGENASE.REF BIOORG.MED.CHEM.LETT. V. 23 3186 2013REFN ISSN 0960-894XPMID 23628333DOI 10.1016/J.BMCL.2013.04.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2xrc CFI human complement factor i 2.69Å AUTH P.ROVERSI,S.JOHNSON,J.J.CAESAR,F.MCLEAN,K.J.LEATH,AUTH 2 S.A.TSIFTSOGLOU,B.P.MORGAN,C.L.HARRIS,R.B.SIM,S.M.LEATITL STRUCTURAL BASIS FOR COMPLEMENT FACTOR I CONTROL AND ITSTITL 2 DISEASE-ASSOCIATED SEQUENCE POLYMORPHISMS.REF PROC.NATL.ACAD.SCI.USA V. 108 12839 2011REFN ISSN 0027-8424PMID 21768352DOI 10.1073/PNAS.1102167108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2gf9 RAB3D crystal structure of human rab3d in complex with gdp 1.53Å AUTH B.HONG,J.WANG,L.SHEN,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB3D IN COMPLEX WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants