General Structure Information
| PDB ID | 1if4 |
| HGNC Gene Label(s) | CA2 |
| Structure Name | carbonic anhydrase ii complexed with 4- fluorobenzenesulfonamide |
| Resolution | 1.93Å |
| Reference | AUTH C.-Y.KIM,D.W.CHRISTIANSONTITL BINDING OF FLUORINE SUBSTITUTEDTITL 2 BENZENESULFONAMIDES TO CARBONIC ANHYDRASE IIREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 258 |
| Number Of SNVs | 56 |
| Number Of Permutations | 20160 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.01 |
| p-value | 0.027 |
ClinVar
| Number Of Residues | 258 |
| Number Of SNVs | 4 |
| Number Of Permutations | 608 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.0 |
| p-value | 0.301 |
COSMIC
| Number Of Residues | 258 |
| Number Of SNVs | 4 |
| Number Of Permutations | 142 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.167 |
| p-value | 0.242 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 56 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | -0.228 |
| p-value | 0.325 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 56 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.41 |
| p-value | 0.034 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
