General Structure Information
| PDB ID | 4jnk |
| HGNC Gene Label(s) | LDHA |
| Structure Name | lactate dehydrogenase a in complex with inhibitor compound 22 |
| Resolution | 1.9Å |
| Reference | AUTH P.S.DRAGOVICH,B.P.FAUBER,L.B.CORSON,C.Z.DING,C.EIGENBROT,AUTH 2 H.GE,A.M.GIANNETTI,T.HUNSAKER,S.LABADIE,Y.LIU,S.MALEK,B.PAN,AUTH 3 D.PETERSON,K.PITTS,H.E.PURKEY,S.SIDERIS,M.ULTSCH,AUTH 4 E.VANDERPORTEN,B.WEI,Q.XU,I.YEN,Q.YUE,H.ZHANG,X.ZHANGTITL IDENTIFICATION OF SUBSTITUTEDTITL 2 2-THIO-6-OXO-1,6-DIHYDROPYRIMIDINES AS INHIBITORS OF HUMANTITL 3 LACTATE DEHYDROGENASE.REF BIOORG.MED.CHEM.LETT. V. 23 3186 2013REFN ISSN 0960-894XPMID 23628333DOI 10.1016/J.BMCL.2013.04.001 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 331 |
| Number Of SNVs | 67 |
| Number Of Permutations | 56432 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.016 |
| p-value | 0.593 |
COSMIC
| Number Of Residues | 331 |
| Number Of SNVs | 6 |
| Number Of Permutations | 3876 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.467 |
| p-value | 0.364 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 67 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.212 |
| p-value | 0.471 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
