General Structure Information
| PDB ID | 1zed |
| HGNC Gene Label(s) | ALPP |
| Structure Name | alkaline phosphatase from human placenta in complex with p- nitrophenyl-phosphonate |
| Resolution | 1.57Å |
| Reference | AUTH P.LLINAS,E.A.STURA,A.MENEZ,Z.KISS,T.STIGBRAND,J.L.MILLAN,AUTH 2 M.H.LE DUTITL STRUCTURAL STUDIES OF HUMAN PLACENTAL ALKALINE PHOSPHATASETITL 2 IN COMPLEX WITH FUNCTIONAL LIGANDS.REF J.MOL.BIOL. V. 350 441 2005REFN ISSN 0022-2836PMID 15946677DOI 10.1016/J.JMB.2005.04.068 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 481 |
| Number Of SNVs | 88 |
| Number Of Permutations | 46708 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.145 |
| p-value | 0.0 |
COSMIC
| Number Of Residues | 481 |
| Number Of SNVs | 12 |
| Number Of Permutations | 4038 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.03 |
| p-value | 0.92 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 88 |
| Number Of COSMIC SNVs | 11 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | -0.065 |
| p-value | 0.49 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
