Assessment of Structural Intolerance and Durability
General Structure Information 1owa SPTA1 solution structural studies on human erythrocyte alpha spectrin n terminal tetramerization domain -1.0Å AUTH S.PARK,M.S.CAFFREY,M.E.JOHNSON,L.W.FUNGTITL SOLUTION STRUCTURAL STUDIES ON HUMAN ERYTHROCYTETITL 2 ALPHA-SPECTRIN TETRAMERIZATION SITE.REF J.BIOL.CHEM. V. 278 21837 2003REFN ISSN 0021-9258PMID 12672815DOI 10.1074/JBC.M300617200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1shr HBD crystal structure of ferrocyanide bound human hemoglobin a2 at 1.88a resolution 1.88Å AUTH U.SEN,J.DASGUPTA,D.CHOUDHURY,P.DATTA,A.CHAKRABARTI,AUTH 2 S.B.CHAKRABARTY,A.CHAKRABARTY,J.K.DATTAGUPTATITL CRYSTAL STRUCTURES OF HBA2 AND HBE AND MODELING OFTITL 2 HEMOGLOBIN DELTA4: INTERPRETATION OF THE THERMALTITL 3 STABILITY AND THE ANTISICKLING EFFECT OF HBA2 ANDTITL 4 IDENTIFICATION OF THE FERROCYANIDE BINDING SITE INTITL 5 […]
General Structure Information 2vwm F10 aminopyrrolidine factor xa inhibitor 1.96Å AUTH K.G.ZBINDEN,L.ANSELM,D.W.BANNER,J.M.BENZ,F.BLASCO,AUTH 2 G.DECORET,J.HIMBER,B.KUHN,N.PANDAY,F.RICKLIN,AUTH 3 P.RISCH,D.SCHLATTER,M.STAHL,S.THOMI,R.UNGER,W.HAAPTITL DESIGN OF NOVEL AMINOPYRROLIDINE FACTOR XATITL 2 INHIBITORS FROM A SCREENING HIT.REF EUR.J.MED.CHEM. V. 44 2787 2009REFN ISSN 0223-5234PMID 19200624DOI 10.1016/J.EJMECH.2008.12.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ifg NTRK1 structure of the extracellular segment of human trka in complex with nerve growth factor 3.4Å AUTH T.WEHRMAN,X.HE,B.RAAB,A.DUKIPATTI,H.BLAU,K.C.GARCIATITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO NERVE GROWTH FACTORTITL 2 INTERACTIONS WITH THE TRKA AND P75 RECEPTORS.REF NEURON V. 53 25 2007REFN ISSN 0896-6273PMID 17196528DOI 10.1016/J.NEURON.2006.09.034 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2ifg NGF structure of the extracellular segment of human trka in complex with nerve growth factor 3.4Å AUTH T.WEHRMAN,X.HE,B.RAAB,A.DUKIPATTI,H.BLAU,K.C.GARCIATITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO NERVE GROWTH FACTORTITL 2 INTERACTIONS WITH THE TRKA AND P75 RECEPTORS.REF NEURON V. 53 25 2007REFN ISSN 0896-6273PMID 17196528DOI 10.1016/J.NEURON.2006.09.034 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2wnv C1QC complex between c1q globular heads and deoxyribose 1.25Å AUTH V.GARLATTI,A.CHOUQUET,T.LUNARDI,R.VIVES,H.PAIDASSI,AUTH 2 H.LORTAT-JACOB,N.M.THIELENS,G.J.ARLAUD,C.GABORIAUDTITL CUTTING EDGE: C1Q BINDS DEOXYRIBOSE AND HEPARANTITL 2 SULFATE THROUGH NEIGHBORING SITES OF ITSTITL 3 RECOGNITION DOMAIN.REF J.IMMUNOL. V. 185 808 2010REFN ISSN 0022-1767PMID 20548024DOI 10.4049/JIMMUNOL.1000184 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1eer EPO crystal structure of human erythropoietin complexed to its receptor at 1.9 angstroms 1.9Å AUTH R.S.SYED,S.W.REID,C.LI,J.C.CHEETHAM,K.H.AOKI,B.LIU,AUTH 2 H.ZHAN,T.D.OSSLUND,A.J.CHIRINO,J.ZHANG,AUTH 3 J.FINER-MOORE,S.ELLIOTT,K.SITNEY,B.A.KATZ,AUTH 4 D.J.MATTHEWS,J.J.WENDOLOSKI,J.EGRIE,R.M.STROUDTITL EFFICIENCY OF SIGNALLING THROUGH CYTOKINETITL 2 RECEPTORS DEPENDS CRITICALLY ON RECEPTORTITL 3 ORIENTATION.REF NATURE V. 395 511 1998REFN ISSN 0028-0836PMID 9774108DOI 10.1038/26773 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1n7d LDLR extracellular domain of the ldl receptor 3.7Å AUTH G.RUDENKO,L.HENRY,K.HENDERSON,K.ICHTCHENKO,M.S.BROWN,AUTH 2 J.L.GOLDSTEIN,J.DEISENHOFERTITL STRUCTURE OF THE LDL RECEPTOR EXTRACELLULAR DOMAIN ATTITL 2 ENDOSOMAL PHREF SCIENCE V. 298 2353 2002REFN ISSN 0036-8075PMID 12459547DOI 10.1126/SCIENCE.1078124 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2i0e PRKCB structure of catalytic domain of human protein kinase c beta ii complexed with a bisindolylmaleimide inhibitor 2.6Å AUTH N.GRODSKY,Y.LI,D.BOUZIDA,R.LOVE,J.JENSEN,B.NODES,AUTH 2 J.NONOMIYA,S.GRANTTITL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PROTEINTITL 2 KINASE C BETA II COMPLEXED WITH ATITL 3 BISINDOLYLMALEIMIDE INHIBITORREF BIOCHEMISTRY V. 45 13970 2006REFN ISSN 0006-2960PMID 17115692DOI 10.1021/BI061128H Variant […]
General Structure Information 2anw KLKB1 expression, crystallization and three-dimensional structure of the catalytic domain of human plasma kallikrein: implications for structure-based design of protease inhibitors 1.85Å AUTH J.TANG,C.L.YU,S.R.WILLIAMS,E.SPRINGMAN,D.JEFFERY,AUTH 2 P.A.SPRENGELER,A.ESTEVEZ,J.SAMPANG,W.SHRADER,AUTH 3 J.SPENCER,W.YOUNG,M.MCGRATH,B.A.KATZTITL EXPRESSION, CRYSTALLIZATION, AND THREE-DIMENSIONALTITL 2 STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PLASMATITL 3 KALLIKREIN.REF J.BIOL.CHEM. V. 280 41077 2005REFN ISSN 0021-9258PMID 16199530DOI […]