Assessment of Structural Intolerance and Durability
General Structure Information 2wpi F9 factor ixa superactive double mutant 1.99Å AUTH T.ZOGG,H.BRANDSTETTERTITL STRUCTURAL BASIS OF THE COFACTOR- ANDTITL 2 SUBSTRATE-ASSISTED ACTIVATION OF HUMAN COAGULATIONTITL 3 FACTOR IXAREF STRUCTURE V. 17 1669 2009REFN ISSN 0969-2126PMID 20004170DOI 10.1016/J.STR.2009.10.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3e7c NR3C1 glucocorticoid receptor lbd bound to gsk866 2.15Å AUTH K.P.MADAUSS,R.K.BLEDSOE,I.MCLAY,E.L.STEWART,I.J.UINGS,AUTH 2 G.WEINGARTEN,S.P.WILLIAMSTITL THE FIRST X-RAY CRYSTAL STRUCTURE OF THE GLUCOCORTICOIDTITL 2 RECEPTOR BOUND TO A NON-STEROIDAL AGONIST.REF BIOORG.MED.CHEM.LETT. V. 18 6097 2008REFN ISSN 0960-894XPMID 18952422DOI 10.1016/J.BMCL.2008.10.021 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1qdd REG1A crystal structure of human lithostathine to 1.3 a resolution 1.3Å AUTH V.GERBAUD,D.PIGNOL,E.LORET,J.A.BERTRAND,Y.BERLAND,AUTH 2 J.C.FONTECILLA-CAMPS,J.P.CANSELIER,N.GABAS,AUTH 3 J.M.VERDIERTITL MECHANISM OF CALCITE CRYSTAL GROWTH INHIBITION BYTITL 2 THE N-TERMINAL UNDECAPEPTIDE OF LITHOSTATHINE.REF J.BIOL.CHEM. V. 275 1057 2000REFN ISSN 0021-9258PMID 10625646DOI 10.1074/JBC.275.2.1057 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3b2d LY86 crystal structure of human rp105/md-1 complex 2.8Å AUTH U.OHTO,K.MIYAKE,T.SHIMIZUTITL CRYSTAL STRUCTURES OF MOUSE AND HUMAN RP105/MD-1 COMPLEXESTITL 2 REVEAL UNIQUE DIMER ORGANIZATION OF THE TOLL-LIKE RECEPTORTITL 3 FAMILY.REF J.MOL.BIOL. V. 413 815 2011REFN ISSN 0022-2836PMID 21959264DOI 10.1016/J.JMB.2011.09.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2nn7 CA1 structure of inhibitor binding to carbonic anhydrase i 1.85Å AUTH D.K.SRIVASTAVA,K.M.JUDE,A.L.BANERJEE,M.HALDAR,AUTH 2 S.MANOKARAN,J.KOOREN,S.MALLIK,D.W.CHRISTIANSONTITL STRUCTURAL ANALYSIS OF CHARGE DISCRIMINATION INTITL 2 THE BINDING OF INHIBITORS TO HUMAN CARBONICTITL 3 ANHYDRASES I AND II.REF J.AM.CHEM.SOC. V. 129 5528 2007REFN ISSN 0002-7863PMID 17407288DOI 10.1021/JA068359W Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1hyn SLC4A1 crystal structure of the cytoplasmic domain of human erythrocyte band-3 protein 2.6Å AUTH D.ZHANG,A.KIYATKIN,J.T.BOLIN,P.S.LOWTITL CRYSTALLOGRAPHIC STRUCTURE AND FUNCTIONALTITL 2 INTERPRETATION OF THE CYTOPLASMIC DOMAIN OFTITL 3 ERYTHROCYTE MEMBRANE BAND 3.REF BLOOD V. 96 2925 2000REFN ISSN 0006-4971PMID 11049968 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3sdl ISG15 crystal structure of human isg15 in complex with ns1 n-terminal region from influenza b virus, northeast structural genomics consortium target ids hx6481, hr2873, and or2 2.29Å AUTH R.GUAN,L.C.MA,P.G.LEONARD,B.R.AMER,H.SRIDHARAN,C.ZHAO,AUTH 2 R.M.KRUG,G.T.MONTELIONETITL STRUCTURAL BASIS FOR THE SEQUENCE-SPECIFIC RECOGNITION OFTITL 2 HUMAN ISG15 BY THE NS1 PROTEIN OF INFLUENZA B VIRUS.REF PROC.NATL.ACAD.SCI.USA V. […]
General Structure Information 2ggz GUCA1C crystal structure of human guanylate cyclase activating protein-3 3.0Å AUTH R.STEPHEN,K.PALCZEWSKI,M.C.SOUSATITL THE CRYSTAL STRUCTURE OF GCAP3 SUGGESTS MOLECULARTITL 2 MECHANISM OF GCAP-LINKED CONE DYSTROPHIES.REF J.MOL.BIOL. V. 359 266 2006REFN ISSN 0022-2836PMID 16626734DOI 10.1016/J.JMB.2006.03.042 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1su3 MMP1 x-ray structure of human prommp-1: new insights into collagenase action 2.2Å AUTH D.JOZIC,G.BOURENKOV,N.H.LIM,R.VISSE,H.NAGASE,AUTH 2 W.BODE,K.MASKOSTITL X-RAY STRUCTURE OF HUMAN PROMMP-1: NEW INSIGHTSTITL 2 INTO PROCOLLAGENASE ACTIVATION AND COLLAGENTITL 3 BINDING.REF J.BIOL.CHEM. V. 280 9578 2005REFN ISSN 0021-9258PMID 15611040DOI 10.1074/JBC.M411084200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3con NRAS crystal structure of the human nras gtpase bound with gdp 1.65Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,L.SHEN,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN NRAS GTPASE BOUNDTITL 2 WITH GDP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants