General Structure Information
| PDB ID | 3sdl |
| HGNC Gene Label(s) | ISG15 |
| Structure Name | crystal structure of human isg15 in complex with ns1 n-terminal region from influenza b virus, northeast structural genomics consortium target ids hx6481, hr2873, and or2 |
| Resolution | 2.29Å |
| Reference | AUTH R.GUAN,L.C.MA,P.G.LEONARD,B.R.AMER,H.SRIDHARAN,C.ZHAO,AUTH 2 R.M.KRUG,G.T.MONTELIONETITL STRUCTURAL BASIS FOR THE SEQUENCE-SPECIFIC RECOGNITION OFTITL 2 HUMAN ISG15 BY THE NS1 PROTEIN OF INFLUENZA B VIRUS.REF PROC.NATL.ACAD.SCI.USA V. 108 13468 2011REFN ISSN 0027-8424PMID 21808041DOI 10.1073/PNAS.1107032108 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 151 |
| Number Of SNVs | 50 |
| Number Of Permutations | 6683 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.229 |
| p-value | 0.094 |
COSMIC
| Number Of Residues | 151 |
| Number Of SNVs | 4 |
| Number Of Permutations | 16 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 50 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.414 |
| p-value | 0.283 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
