General Structure Information
| PDB ID | 2vwm |
| HGNC Gene Label(s) | F10 |
| Structure Name | aminopyrrolidine factor xa inhibitor |
| Resolution | 1.96Å |
| Reference | AUTH K.G.ZBINDEN,L.ANSELM,D.W.BANNER,J.M.BENZ,F.BLASCO,AUTH 2 G.DECORET,J.HIMBER,B.KUHN,N.PANDAY,F.RICKLIN,AUTH 3 P.RISCH,D.SCHLATTER,M.STAHL,S.THOMI,R.UNGER,W.HAAPTITL DESIGN OF NOVEL AMINOPYRROLIDINE FACTOR XATITL 2 INHIBITORS FROM A SCREENING HIT.REF EUR.J.MED.CHEM. V. 44 2787 2009REFN ISSN 0223-5234PMID 19200624DOI 10.1016/J.EJMECH.2008.12.025 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 225 |
| Number Of SNVs | 58 |
| Number Of Permutations | 19131 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.015 |
| p-value | 0.261 |
COSMIC
| Number Of Residues | 225 |
| Number Of SNVs | 8 |
| Number Of Permutations | 3763 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.036 |
| p-value | 0.739 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 58 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | -0.056 |
| p-value | 0.923 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
