General Structure Information
| PDB ID | 1eer |
| HGNC Gene Label(s) | EPO |
| Structure Name | crystal structure of human erythropoietin complexed to its receptor at 1.9 angstroms |
| Resolution | 1.9Å |
| Reference | AUTH R.S.SYED,S.W.REID,C.LI,J.C.CHEETHAM,K.H.AOKI,B.LIU,AUTH 2 H.ZHAN,T.D.OSSLUND,A.J.CHIRINO,J.ZHANG,AUTH 3 J.FINER-MOORE,S.ELLIOTT,K.SITNEY,B.A.KATZ,AUTH 4 D.J.MATTHEWS,J.J.WENDOLOSKI,J.EGRIE,R.M.STROUDTITL EFFICIENCY OF SIGNALLING THROUGH CYTOKINETITL 2 RECEPTORS DEPENDS CRITICALLY ON RECEPTORTITL 3 ORIENTATION.REF NATURE V. 395 511 1998REFN ISSN 0028-0836PMID 9774108DOI 10.1038/26773 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 166 |
| Number Of SNVs | 47 |
| Number Of Permutations | 7745 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.105 |
| p-value | 0.209 |
COSMIC
| Number Of Residues | 166 |
| Number Of SNVs | 4 |
| Number Of Permutations | 45 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.333 |
| p-value | 0.713 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 47 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.308 |
| p-value | 0.451 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
