General Structure Information
| PDB ID | 2ifg |
| HGNC Gene Label(s) | NGF |
| Structure Name | structure of the extracellular segment of human trka in complex with nerve growth factor |
| Resolution | 3.4Å |
| Reference | AUTH T.WEHRMAN,X.HE,B.RAAB,A.DUKIPATTI,H.BLAU,K.C.GARCIATITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO NERVE GROWTH FACTORTITL 2 INTERACTIONS WITH THE TRKA AND P75 RECEPTORS.REF NEURON V. 53 25 2007REFN ISSN 0896-6273PMID 17196528DOI 10.1016/J.NEURON.2006.09.034 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 108 |
| Number Of SNVs | 28 |
| Number Of Permutations | 6303 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.526 |
| p-value | 0.139 |
COSMIC
| Number Of Residues | 108 |
| Number Of SNVs | 5 |
| Number Of Permutations | 478 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.1 |
| p-value | 0.378 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 28 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | -0.268 |
| p-value | 0.573 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
