General Structure Information
| PDB ID | 2i0e |
| HGNC Gene Label(s) | PRKCB |
| Structure Name | structure of catalytic domain of human protein kinase c beta ii complexed with a bisindolylmaleimide inhibitor |
| Resolution | 2.6Å |
| Reference | AUTH N.GRODSKY,Y.LI,D.BOUZIDA,R.LOVE,J.JENSEN,B.NODES,AUTH 2 J.NONOMIYA,S.GRANTTITL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PROTEINTITL 2 KINASE C BETA II COMPLEXED WITH ATITL 3 BISINDOLYLMALEIMIDE INHIBITORREF BIOCHEMISTRY V. 45 13970 2006REFN ISSN 0006-2960PMID 17115692DOI 10.1021/BI061128H |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 300 |
| Number Of SNVs | 43 |
| Number Of Permutations | 21006 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.238 |
| p-value | 0.145 |
COSMIC
| Number Of Residues | 300 |
| Number Of SNVs | 11 |
| Number Of Permutations | 2661 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.327 |
| p-value | 0.947 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 43 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.081 |
| p-value | 0.629 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
