General Structure Information
| PDB ID | 2anw |
| HGNC Gene Label(s) | KLKB1 |
| Structure Name | expression, crystallization and three-dimensional structure of the catalytic domain of human plasma kallikrein: implications for structure-based design of protease inhibitors |
| Resolution | 1.85Å |
| Reference | AUTH J.TANG,C.L.YU,S.R.WILLIAMS,E.SPRINGMAN,D.JEFFERY,AUTH 2 P.A.SPRENGELER,A.ESTEVEZ,J.SAMPANG,W.SHRADER,AUTH 3 J.SPENCER,W.YOUNG,M.MCGRATH,B.A.KATZTITL EXPRESSION, CRYSTALLIZATION, AND THREE-DIMENSIONALTITL 2 STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PLASMATITL 3 KALLIKREIN.REF J.BIOL.CHEM. V. 280 41077 2005REFN ISSN 0021-9258PMID 16199530DOI 10.1074/JBC.M506766200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 222 |
| Number Of SNVs | 64 |
| Number Of Permutations | 22391 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.116 |
| p-value | 0.279 |
COSMIC
| Number Of Residues | 222 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1670 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.133 |
| p-value | 0.867 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 64 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.084 |
| p-value | 0.702 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
