4MZR.B | TP53

General Structure Information

PDB ID 4mzr
HGNC Gene Label(s) TP53
Structure Name crystal structure of a polypeptide p53 mutant bound to dna
Resolution 2.9Å
Reference AUTH S.EMAMZADAH,L.TROPIA,I.VINCENTI,B.FALQUET,T.D.HALAZONETISTITL REVERSAL OF THE DNA-BINDING-INDUCED LOOP L1 CONFORMATIONALTITL 2 SWITCH IN AN ENGINEERED HUMAN P53 PROTEIN.REF J.MOL.BIOL. V. 426 936 2014REFN ISSN 0022-2836PMID 24374182DOI 10.1016/J.JMB.2013.12.020

Variant Set Distributions

ExAC Variants

Number Of Residues 234
Number Of SNVs 58
Number Of Permutations 30689
Optimal Distance Threshold 6.0
K Statistic 0.024
p-value 0.684
ClinVar

Number Of Residues 234
Number Of SNVs 57
Number Of Permutations 29982
Optimal Distance Threshold 10.0
K Statistic 0.117
p-value 0.0
COSMIC

Number Of Residues 234
Number Of SNVs 150
Number Of Permutations 77066
Optimal Distance Threshold 8.0
K Statistic 0.05
p-value 0.0

Ripley’s K Analysis Plots

ExACClinVarCOSMIC

Variant Set Comparisons

ClinVar vs. ExAC

Number Of ExAC SNVs 58
Number Of ClinVar SNVs 46
Optimal Distance Threshold 17.0
K Statistic 0.13
p-value 0.01
Cosmic vs. ExAC

Number Of ExAC SNVs 58
Number Of COSMIC SNVs 25
Optimal Distance Threshold 5.0
K Statistic 0.01
p-value 0.971

Pathogenic Proximity Analysis

ClinVar PathProx Analysis
COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] ClinVar Missense Variants

[+] COSMIC Missense Variants

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